SML0552
替拉扎明
≥98% (HPLC), Pro-apoptotic, powder
别名:
4-羟基-1-氧-1,2,4-苯并三嗪-1-鎓-3-亚胺, SR 259075, SR 4233, Win 59075, 三嗪酮
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关于此项目
经验公式（希尔记法）:
C7H6N4O2
化学文摘社编号:
分子量:
178.15
UNSPSC Code:
12352116
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
替拉扎明, ≥98% (HPLC)
SMILES string
Nc1n[n+]([O-])c2ccccc2[n+]1[O-]
InChI
1S/C7H6N4O2/c8-7-9-11(13)6-4-2-1-3-5(6)10(7)12/h1-4H,(H2,8,9)
InChI key
ORYDPOVDJJZGHQ-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
, orange to dark orange-red
solubility
DMSO: 10 mg/mL, clear
shipped in
wet ice
storage temp.
−20°C
Quality Level
相关类别
Application
已经使用替拉扎明评估其对U-251 MG（成胶质细胞瘤细胞系）细胞活力的细胞毒性作用。
Biochem/physiol Actions
在低氧条件下，替拉扎明是一种有效的细胞毒性剂，通过诱导单链和双链DNA的断裂以及染色体断裂诱导细胞凋亡。 该化合物可使细胞对其他电离辐射和其他细胞毒性药物（如顺铂）敏感。
在缺氧条件下，替拉扎明是有效的细胞毒性药物。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Yunzhou Shi et al.
Neoplasia (New York, N.Y.), 19(11), 950-959 (2017-10-11)
The effect of anti-angiogenic agents on tumor oxygenation has been in question for a number of years, where both increases and decreases in tumor pO
Development and characterization of a microfluidic model of the tumour microenvironment.
Ayuso J M, et al.
Scientific Reports, 6, 36086-36086 (2016)
Yao Tang et al.
Theranostics, 10(19), 8691-8704 (2020-08-06)
Rationale: Nanoscale vehicles responsive to abnormal variation in tumor environment are promising for use in targeted delivery of therapeutic drugs specifically to tumor sites. Herein, we report the design and fabrication of self-accelerating H2O2-responsive plasmonic gold nanovesicles (GVs) encapsulated with
Yung-Ann Chen et al.
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This paper reports a microfluidic device capable of generating oxygen gradients for cell culture using spatially confined chemical reactions with minimal chemical consumption. The microfluidic cell culture device is constructed by single-layer polydimethylsiloxane (PDMS) microfluidic channels, in which the cells
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