SML0558
BETP
≥98% (HPLC)
别名:
2-(乙基亚磺酰基)-4- [3-(苯基甲氧基)苯基] -6-(三氟甲基)-嘧啶
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关于此项目
经验公式（希尔记法）:
C20H17F3N2O2S
化学文摘社编号:
分子量:
406.42
MDL编号:
UNSPSC代码:
51111800
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 5 mg/mL, clear (warmed)
储存温度
2-8°C
SMILES字符串
CCS(=O)c1nc(cc(n1)C(F)(F)F)-c2cccc(OCc3ccccc3)c2
InChI
1S/C20H17F3N2O2S/c1-2-28(26)19-24-17(12-18(25-19)20(21,22)23)15-9-6-10-16(11-15)27-13-14-7-4-3-5-8-14/h3-12H,2,13H2,1H3
InChI key
NTDFYGSSDDMNHI-UHFFFAOYSA-N
生化/生理作用
BETP是GLP-1受体的一种正变构调节剂，在弱GLP-1代谢产物GLP-1（9-36）存在的情况下可增强胰岛细胞中cAMP的积累和葡萄糖依赖性胰岛素的释放。BETP对内源性GLP-1受体配体GLP-1（7-36）具有累加作用。
BETP是一种GLP-1受体变构调节剂。
BetP是一种三聚Na+偶联的甜菜碱同向转运蛋白。BetP属于甜菜碱-胆碱-肉碱转运蛋白（BCCT）家族。它可根据细胞质K+浓度而控制转运活性。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Khyati Girdhar et al.
Journal of biomolecular structure & dynamics, 37(15), 3976-3986 (2018-10-10)
The glucagon-like peptide-1 receptor (GLP-1R) is a well-known target of therapeutics industries for the treatment of various metabolic diseases like type 2 diabetes and obesity. The structural-functional relationships of small molecule agonists and GLP-1R are yet to be understood. Therefore
Locating an extracellular K+-dependent interaction site that modulates betaine-binding of the Na+-coupled betaine symporter BetP.
Ge L, et al.
Proceedings of the National Academy of Sciences of the USA (2011)
C Weston et al.
British journal of pharmacology, 171(15), 3651-3665 (2014-04-10)
The glucagon-like peptide 1 (GLP-1) receptor performs an important role in glycaemic control, stimulating the release of insulin. It is an attractive target for treating type 2 diabetes. Recently, several reports of adverse side effects following prolonged use of GLP-1
Lipid-protein interactions in the regulated betaine symporter BetP probed by infrared spectroscopy.
Guler G, et al.
The Journal of Biological Chemistry, 291(9), 4295-4307 (2016)
Daniela G Dengler et al.
SLAS discovery : advancing life sciences R & D, 26(1), 1-16 (2020-08-05)
The secretin receptor (SCTR), a prototypical class B G protein-coupled receptor (GPCR), exerts its effects mainly by activating Gαs proteins upon binding of its endogenous peptide ligand secretin. SCTRs can be found in a variety of tissues and organs across
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