SML0574
YM-298198 hydrochloride
≥98% (HPLC)
别名:
6-Amino-N-cyclohexyl-N,3-dimethyl-thiazolo[3,2-a]benzimidazole-2-carboxamide hydrochloride
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选择尺寸
关于此项目
经验公式（希尔记法）:
C18H22N4OS · HCl
化学文摘社编号:
分子量:
378.92
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C18H22N4OS.ClH/c1-11-16(17(23)21(2)13-6-4-3-5-7-13)24-18-20-14-9-8-12(19)10-15(14)22(11)18;/h8-10,13H,3-7,19H2,1-2H3;1H
SMILES string
Cl.CN(C1CCCCC1)C(=O)c2sc3nc4ccc(N)cc4n3c2C
InChI key
WYTJVUVCSUWZTH-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 5 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
YM-298198 is a selective, noncompetitive mGlu1 receptor antagonist.
YM-298198 is an orally active, noncompetitive mGlu1 receptor antagonist. The compound inhibits glutamate-induced inositol phosphate production in NIH3T3 cells (IC50 = 16 nM). YM-298198 displays analgesic and antinociceptive properties in vivo.
Features and Benefits
This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Haein Weon et al.
Life sciences, 188, 110-117 (2017-09-09)
Both N-type and P/Q-type voltage-gated Ca (S)-3,5-Dihydroxyphenylglycine (DHPG; 10μM for 5min), the group I mGluR agonist, was used to induce LTP of excitatory postsynaptic currents that were evoked in the Vo neurons by stimulating the trigeminal track. Weak blockade of
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