SML0584
NNGH
≥98% (HPLC)
别名:
BML-205, N-Isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid
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关于此项目
经验公式（希尔记法）:
C13H20N2O5S
化学文摘社编号:
分子量:
316.37
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
NNGH, ≥98% (HPLC)
InChI
1S/C13H20N2O5S/c1-10(2)8-15(9-13(16)14-17)21(18,19)12-6-4-11(20-3)5-7-12/h4-7,10,17H,8-9H2,1-3H3,(H,14,16)
SMILES string
COc1ccc(cc1)S(=O)(=O)N(CC(C)C)CC(=O)NO
InChI key
JIRXORZYIXSWOB-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 15 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
NNGH is a potent and cell-permeable inhibitor of matrix metalloproteinase 3 (MMP-3,stromelysin 1, progelatinase).
NNGH is a potent and cell-permeable inhibitor of matrix metalloproteinase 3 (MMP-3,stromelysin 1, progelatinase). NNGH has been used to inhibit MMP-3 in a variety of studies. Inhibition of MMP-3 with NNGH significantly suppressed the expression of iNOS and pro-inflammatory cytokines and the activities of NF-KB, AP-1, and MAPK in LPS-stimulated microglia, suggesting a role for MMP-3 in neuroinflammation.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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American journal of physiology. Gastrointestinal and liver physiology, 306(11), G992-G1001 (2014-04-20)
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Current eye research, 45(5), 591-603 (2019-10-31)
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Sandra Rother et al.
Acta biomaterialia, 45, 143-154 (2016-10-19)
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Anthony Martin et al.
Journal of cellular physiology, 232(12), 3798-3807 (2017-02-19)
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Ekrem-Murat Gonulalan et al.
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 27(3), 446-452 (2019-04-13)
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