SML0594
CGP 55845 盐酸盐
≥98% (HPLC), GABA-B receptor antagonist, powder
别名:
(2S)-3-[[(1S)-1-（3,4-二氯苯基）乙基] 氨基-2-羟基丙基]（苯甲基）次膦酸 盐酸盐, CGP 55845A, CGP55845
产品名称
CGP 55845 盐酸盐, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to beige
溶解性
DMSO: 5 mg/mL, clear (warmed)
储存温度
room temp
SMILES字符串
[P](=O)(O)(C[C@@H](O)CN[C@@H](C)c2cc(c(cc2)Cl)Cl)Cc1ccccc1
InChI
1S/C18H22Cl2NO3P/c1-13(15-7-8-17(19)18(20)9-15)21-10-16(22)12-25(23,24)11-14-5-3-2-4-6-14/h2-9,13,16,21-22H,10-12H2,1H3,(H,23,24)/t13-,16-/m0/s1
InChI key
ZODSPDOOCZZEIM-BBRMVZONSA-N
相关类别
生化/生理作用
CGP 55845 是一种强效选择性 GABA-B IC 50 为 5 nM 的受体拮抗剂。
CGP 55845 是一种强效选择性 GABA-B 受体拮抗剂。
特点和优势
这种化合物是神经科学研究的特色产品。点击此处发现更多特色神经科学产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Michael H Myoga et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(14), 5235-5243 (2011-04-08)
R-type calcium channels in postsynaptic spines signal through functional calcium microdomains to regulate a calcium/calmodulin-sensitive potassium channel that in turn regulates postsynaptic hippocampal long-term potentiation (LTP). Here, we ask whether R-type calcium channels in presynaptic terminals also signal through calcium
Ahmad A Khundakar et al.
European journal of pharmacology, 671(1-3), 33-38 (2011-09-21)
Brain-derived neurotrophic factor (BDNF) has been suggested as a target for antidepressant treatment and chronic antidepressant drug administration shows a 'biphasic effect' on BDNF mRNA in rat hippocampus (transient decrease followed by an increase). In comparison, following acute administration only
Wendy W Wu et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(7), 2638-2648 (2011-02-18)
Premature and uncompensated loss of ovarian hormones following ovariectomy (OVX) elevates the risks of cognitive impairment and dementia. These risks are prevented with estrogen (E(2))-containing hormone replacement therapy initiated shortly following OVX but not after substantial delay. Currently, the cellular
Mark O Cunningham et al.
Epilepsia, 53(7), 1205-1214 (2012-06-13)
We describe a form of very fast oscillation (VFO) in patient electrocorticography (ECoG) recordings, that can occur prior to ictal events, in which the frequency increases steadily from ≈ 30-40 to >120 Hz, over a period of seconds. We dub
Court A Hull et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(14), 5895-5902 (2013-04-05)
Golgi cells (GoCs) are inhibitory interneurons that influence the cerebellar cortical response to sensory input by regulating the excitability of the granule cell layer. While GoC inhibition is essential for normal motor coordination, little is known about the circuit dynamics
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