Merck
CN
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文件

SML0601

Sigma-Aldrich

BPTES

≥95% (HPLC)

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别名:
双-2-(5-苯基乙酰胺基-1,3,4-噻二唑-2-基)乙基硫醚
经验公式（希尔记法）:
C24H24N6O2S3
CAS号:
314045-39-1
分子量:
524.68
MDL编号:
MFCD01079848
PubChem化学物质编号:
329825569
NACRES:
NA.77

质量水平

100

检测方案

≥95% (HPLC)

形式

powder

颜色

white to beige

溶解性

DMSO: 10 mg/mL, clear

储存温度

2-8°C

SMILES字符串

O=C(CC1=CC=CC=C1)NC2=NN=C(S2)CCSCCC3=NN=C(NC(CC4=CC=CC=C4)=O)S3

InChI

1S/C24H24N6O2S3/c31-19(15-17-7-3-1-4-8-17)25-23-29-27-21(34-23)11-13-33-14-12-22-28-30-24(35-22)26-20(32)16-18-9-5-2-6-10-18/h1-10H,11-16H2,(H,25,29,31)(H,26,30,32)

InChI key

MDJIPXYRSZHCFS-UHFFFAOYSA-N

应用

双-2-(5-苯基乙酰胺基-1,3,4-噻二唑-2-基)乙基硫醚（BPTES）已被用作谷氨酰胺酶抑制剂。

生化/生理作用

BPTES是谷氨酰胺酶GLS1（KGA）的选择性抑制剂，GLS1存在于肾和脑中，由myc正向调节，在许多肿瘤和肿瘤细胞系中高度表达。谷氨酰胺酶可将谷氨酰胺转化为谷氨酸，谷氨酸是脑中重要的兴奋性神经递质，可进一步氧化成α-酮戊二酸（供给三羧酸（TCA）循环）和谷胱甘肽，谷胱甘肽对控制活性氧（ROS）水平很重要，对癌细胞生长尤为重要。BPTES可减缓胶质瘤细胞的生长。BPTES是一种非竞争性抑制剂，Ki为3 μmM。
牛痘病毒（VACV）需要谷氨酰胺代谢才能实现最佳复制。双-2-(5-苯基乙酰胺基-1,3,4-噻二唑-2-基)乙基硫醚（BPTES）抑制谷氨酰胺分解可能有望治疗痘病毒感染。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315 - H319 - H335

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Scientific reports, 7(1), 12486-12486 (2017-10-04)
Transforming Growth Factor beta (TGF-β) induces tumor cell migration and invasion. However, its role in inducing metabolic reprogramming is poorly understood. Here we analyzed the metabolic profile of hepatocellular carcinoma (HCC) cells that show differences in TGF-β expression. Oxygen consumption
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Neutrophils are phenotypically heterogeneous and exert either anti- or pro-metastatic functions. We show that cancer-cell-derived G-CSF is necessary, but not sufficient, to mobilize immature low-density neutrophils (iLDNs) that promote liver metastasis. In contrast, mature high-density neutrophils inhibit the formation of
Roberta Palorini et al.
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Cancer cells often rely on glycolysis to obtain energy and support anabolic growth. Several studies showed that glycolytic cells are susceptible to cell death when subjected to low glucose availability or to lack of glucose. However, some cancer cells, including
Jorge Domínguez-Andrés et al.
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