SML0604
SB-399885 hydrochloride
≥98% (HPLC)
别名:
N-(3,5-Dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)-benzenesulfonamide hydrochloride
SMILES string
[S](=O)(=O)(Nc3c(c(cc(c3)Cl)Cl)OC)c1cc(c(cc1)OC)N2CCNCC2
InChI
1S/C18H21Cl2N3O4S/c1-26-17-4-3-13(11-16(17)23-7-5-21-6-8-23)28(24,25)22-15-10-12(19)9-14(20)18(15)27-2/h3-4,9-11,21-22H,5-8H2,1-2H3
InChI key
ATKZKAYWARYLBW-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 15 mg/mL, clear
storage temp.
room temp
Quality Level
Biochem/physiol Actions
SB-399885 is a potent, selective, and orally active 5-HT6 receptor antagonist with greater than 200 fold selectivity over other 5-HT receptors. SB-399885 is brain penetrant and displays antidepressant and anxiolytic activity in rodent models.
SB-399885 is a potent, selective, and orally active 5-HT6 receptor antagonist; brain penetrant.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Ao Li et al.
CNS neuroscience & therapeutics, 27(8), 941-950 (2021-05-12)
General anesthesia has been widely applied in surgical or nonsurgical medical procedures, but the mechanism behind remains elusive. Because of shared neural circuits of sleep and anesthesia, whether serotonergic system, which is highly implicated in modulation of sleep and wakefulness
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