InChI
1S/C7H5IN2O3/c8-5-2-1-4(7(9)11)3-6(5)10(12)13/h1-3H,(H2,9,11)
InChI key
MDOJTZQKHMAPBK-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear
storage temp.
room temp
General description
Iniparib is also called as BSI-201. It is an anticancer agent.
Biochem/physiol Actions
4-iodo-3-nitrobenzamide, the intracellular metabolite of iniparib has the capability to covalently prevent PARP1 (poly(ADP-Ribose) polymerase 1) under cell-free conditions. PARP inhibitor also plays a role in BRCA (breast cancer susceptibility protein) deficient tumors.
Iniparib (BSI-201) is an antineoplastic originally thought to be a poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor. Recent studies indicate Iniparib is not a PARP-1 inhibitor, and its mechanism of action is currently unknown.
Iniparib (BSI-201) is an antineoplastic.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Failure of iniparib to inhibit poly (ADP-Ribose) polymerase in vitro.
Patel AG, et al.
Clinical Cancer Research, 18(6), 1655?1662-1655?1662 (2012)
Evidence for the efficacy of Iniparib, a PARP-1 inhibitor, in BRCA2-associated pancreatic cancer.
Fogelman DR, et al.
Anticancer Research, 31(4), 1417-1420 (2011)
Iniparib plus chemotherapy in metastatic triple-negative breast cancer.
O'Shaughnessy J, et al.
The New England Journal of Medicine, 364(3), 205-214 (2011)
Hyomin Park et al.
Free radical biology & medicine, 204, 195-206 (2023-05-06)
The important pathway toward liver fibrosis is the TGF-β1-induced activation of hepatic stellate cells (HSCs). To discover chemicals to inhibit liver fibrosis, we screened 3000 chemicals using cell array system where human HSCs line LX2 cells are activated with TGF-β1.
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