SML0627
ML-SA1
≥95% (HPLC), powder, TRPML channel agonist
别名:
1- [（1,3-二氢-1,3-二氧代-2H-异吲哚-2-基）乙酰基]-1,2,3,4-四氢-2,2,4-三甲基-喹啉, 2-（2-氧代-2-（2,2,4-三甲基-3,4-二氢喹啉-1 (2H)-基）乙基）异吲哚-1,3-二酮, Mucolipin 合成激动剂 1
产品名称
ML-SA1, ≥95% (HPLC)
SMILES string
N3(C(=O)c4c(cccc4)C3=O)CC(=O)N1C(CC(c2c1cccc2)C)(C)C
InChI
1S/C22H22N2O3/c1-14-12-22(2,3)24(18-11-7-6-8-15(14)18)19(25)13-23-20(26)16-9-4-5-10-17(16)21(23)27/h4-11,14H,12-13H2,1-3H3
InChI key
KDDHBJICVBONAX-UHFFFAOYSA-N
assay
≥95% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
2-8°C
Quality Level
Application
ML-SA1 已被用作瞬时受体电位阳离子通道粘脂肽 1 (TRPML1/ML1) 激动剂。
Biochem/physiol Actions
ML-SA1 是溶酶体粘脂素瞬时受体电位通道 (TRPML) 1、2、3 的一种强效选择性细胞渗透性激动剂，可显著增加 HEK293 细胞稳定或短暂表达突变型 TRPML1 通道 ML1-4A 中的 [Ca 2+] cyt。
ML-SA1 是溶酶体粘脂素瞬时受体电位通道 (TRPML) 1、2、3 的强效选择性细胞渗透性激动剂。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Gastric acid secretion from parietal cells is mediated by a Ca2+ efflux channel in the tubulovesicle.
Sahoo N, et al.
Developmental Cell, 41(3), 262-273 (2017)
Dengqin Zhong et al.
Nature communications, 14(1), 3997-3997 (2023-07-07)
Uranium (U) is a well-known nephrotoxicant which forms precipitates in the lysosomes of renal proximal tubular epithelial cells (PTECs) after U-exposure at a cytotoxic dose. However, the roles of lysosomes in U decorporation and detoxification remain to be elucidated. Mucolipin
Hongyan Yu et al.
British journal of cancer, 125(10), 1420-1431 (2021-09-23)
Prostate cancer (Pca) is the most common cancer type among males worldwide. Dysregulation of Ca2+ signaling plays important roles during Pca progression. However, there is lack of information about the role of endolysosomal Ca2+ -permeable channels in Pca progression. The
Simona Ida Scorza et al.
International journal of molecular sciences, 24(2) (2023-01-22)
Lysosomes are acidic Ca2+ storage organelles that actively generate local Ca2+ signaling events to regulate a plethora of cell functions. Here, we characterized lysosomal Ca2+ signals in mouse renal collecting duct (CD) cells and we assessed their putative role in
Wei Xiong Siow et al.
Journal of cell science, 135(6) (2022-03-12)
Liver cancers, including hepatocellular carcinoma (HCC), are the second leading cause of cancer death worldwide, and novel therapeutic strategies are still highly needed. Recently, the endolysosomal cation channel TRPML1 (also known as MCOLN1) has gained focus in cancer research because
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