SML0633
UNC0646
≥98% (HPLC)
别名:
N-(1-Cyclohexyl-4-piperidinyl)-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine
SMILES string
N2(CCC(CC2)Nc3nc(nc5c3cc(c(c5)OCCCN6CCCCC6)OC)N4CCN(CCC4)C(C)C)C1CCCCC1
InChI
1S/C36H59N7O2/c1-28(2)41-19-10-20-43(24-23-41)36-38-32-27-34(45-25-11-18-40-16-8-5-9-17-40)33(44-3)26-31(32)35(39-36)37-29-14-21-42(22-15-29)30-12-6-4-7-13-30/h26-30H,4-25H2,1-3H3,(H,37,38,39)
InChI key
OUKWLRHRXOPODD-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
UNC0646 is potent, selective inhibitor of the methyltransferase G9a, which catalyzes lysine-methylation of histones, and nonhistone proteins including p53.
UNC0646 is potent, selective inhibitor of the methyltransferase G9a.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
David A Vierra et al.
Oncotarget, 8(44), 76443-76457 (2017-11-05)
Fanconi anemia (FA) is a rare disease characterized by congenital defects, bone marrow failure, and atypically early-onset cancers. The FA proteins function cooperatively to repair DNA interstrand crosslinks. A major step in the activation of the pathway is the monoubiquitination
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