SML0646
GMX1778
≥98% (HPLC), nicotinamide phosphoribosyltransferase (NAMPT) inhibitor, powder
别名:
CHS 828, CHS-828, GMX 1778, N-[6-(4-Chlorophenoxy)hexyl]-N′-cyano-N′′-4-pyridinyl-guanidine
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Assay:
≥98% (HPLC)
Form:
powder
产品名称
GMX1778, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
−20°C
SMILES string
Clc1ccc(cc1)OCCCCCCN\C(=N\C#N)\Nc2ccncc2
InChI
1S/C19H22ClN5O/c20-16-5-7-18(8-6-16)26-14-4-2-1-3-11-23-19(24-15-21)25-17-9-12-22-13-10-17/h5-10,12-13H,1-4,11,14H2,(H2,22,23,24,25)
InChI key
BOIPLTNGIAPDBY-UHFFFAOYSA-N
Application
GMX1778 has been used as NAMPT inhibitor, to study its effects on nicotinamide adenine dinucleotide (NAD) contents of SH-SY5Y cells exposed to Vacor.
Biochem/physiol Actions
GMX1778 can regulate redox status and has the ability to simulate ROS in cancer cells.
GMX1778 (CHS-828) is a competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) that exhibits a potent anticancer activity both in vitro and in vivo. GMX1778 exerts a cytotoxic effect by decreasing the cellular level of NAD+. GMX1778 increases intracellular ROS in cancer cells but does not induce ROS in normal cells.
GMX1778 is a competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT).
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable