SML0648
CHR-6494 trifluoroacetate salt
≥98% (HPLC)
别名:
3-(1H-Indazol-5-yl)-N-propyl-imidazo[1,2-b]pyridazin-6-amine trifluoroacetate salt, 3-(1H-Indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine trifluoroacetate salt, CHR 6494 trifluoroacetate salt
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关于此项目
经验公式（希尔记法）:
C16H16N6 · CF3COOH
化学文摘社编号:
分子量:
406.36
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 5 mg/mL, clear (warmed)
储存温度
2-8°C
SMILES字符串
OC(=O)C(F)(F)F.CCCNc1ccc2ncc(-c3ccc4[nH]ncc4c3)n2n1
InChI
1S/C16H16N6.C2HF3O2/c1-2-7-17-15-5-6-16-18-10-14(22(16)21-15)11-3-4-13-12(8-11)9-19-20-13;3-2(4,5)1(6)7/h3-6,8-10H,2,7H2,1H3,(H,17,21)(H,19,20);(H,6,7)
InChI key
ILWYDZNXJQESDI-UHFFFAOYSA-N
相关类别
生化/生理作用
CHR-6494 is a potent and selective Haspin (Haploid Germ Cell-Specific Nuclear Protein Kinase) inhibitor that blocks H3T3ph phosphorylation. CHR-6494 causes cell cycle arrest in G2/M and subsequent apoptosis. CHR-6494 causes an abnormal duplication of centrosomes and mitotic catastrophe in cancer cells.
CHR-6494 is a potent and selective Haspin (Haploid Germ Cell-Specific Nuclear Protein Kinase) inhibitor.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Structure Activity Relationship Studies around DB18, a Potent and Selective Inhibitor of CLK Kinases.
Brahmaiah, et al.
Molecules (Basel), 27 (2022)
Roberto Quadri et al.
iScience, 26(10), 108011-108011 (2023-10-16)
Throughout mitosis, a plethora of processes must be efficiently concerted to ensure cell proliferation and tissue functionality. The mitotic spindle does not only mediate chromosome segregation, but also defines the axis of cellular division, thus determining tissue morphology. Functional spindle
Viet Hung Dao et al.
Molecules (Basel, Switzerland), 26(21) (2021-11-14)
Pim kinases (proviral integration site for Moloney murine leukemia virus kinases) are overexpressed in various types of hematological malignancies and solid carcinomas, and promote cell proliferation and survival. Thus, Pim kinases are validated as targets for antitumor therapy. In this
Bruno Oyallon et al.
Molecules (Basel, Switzerland), 26(4) (2021-02-11)
Proviral integration site for Moloney murine leukemia virus (Pim)-1/2 kinase overexpression has been identified in a variety of hematologic (e.g., multiple myeloma or acute myeloid leukemia (AML)) and solid (e.g., colorectal carcinoma) tumors, playing a key role in cancer progression
Bruno Oyallon et al.
European journal of medicinal chemistry, 154, 101-109 (2018-05-21)
We identified a new series of quinoxaline-2-carboxylic acid derivatives, targeting the human proviral integration site for Moloney murine leukemia virus-1 (HsPim-1) kinase. Seventeen analogues were synthesized providing useful insight into structure-activity relationships studied. Docking studies realized in the ATP pocket
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