SML0674
雷莫司琼 盐酸盐
≥98% (HPLC), 5-HT3 receptor antagonist, powder
别名:
(R)-5-[(1-Methyl-3-indolyl)carbonyl]-4,5,6,7-tetrahydro-1H-benzimidazole hydrochloride, YM-060, YM060
产品名称
雷莫司琼 盐酸盐, ≥98% (HPLC)
方案
≥98% (HPLC)
表单
powder
旋光性
[α]/D -36 to -46°, c = 1 in methanol
储存条件
desiccated
颜色
white to beige
溶解性
H2O: 20 mg/mL, clear
储存温度
−20°C
SMILES字符串
Cl.[n]1(c2c(c(c1)C(=O)[C@@H]3CCc4nc[nH]c4C3)cccc2)C
InChI
1S/C17H17N3O.ClH/c1-20-9-13(12-4-2-3-5-16(12)20)17(21)11-6-7-14-15(8-11)19-10-18-14;/h2-5,9-11H,6-8H2,1H3,(H,18,19);1H/t11-;/m1./s1
InChI key
XIXYTCLDXQRHJO-RFVHGSKJSA-N
相关类别
生化/生理作用
Ramosetron hydrochloride is a potent serotonin 5-HT3 receptor antagonist with higher afinity for the 5-HT3 receptor than other currently available antagonists.
Ramosetron hydrochloride is a potent serotonin 5-HT3 receptor antagonist with higher afinity for the 5-HT3 receptor than other currently available antagonists. Ramosetron is used clinically both as an antiemetic to treat nausea and vomiting following chemotherapy or after surgery, and in treatment of irritable bowel syndrome.
Ramosetron is a tetra hydrobenzimidazole derivative, containing an indole ring. It inhibits colon contraction mediated by serotonin, competitively.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Jung-Hee Ryu et al.
Clinical therapeutics, 33(9), 1162-1172 (2011-08-23)
Patients undergoing general anesthesia for laparoscopic cholecystectomy have a high risk of postoperative nausea and vomiting (PONV) with incidences up to 75%. Ramosetron, a serotonin subtype 3 (5-HT(3)) antagonist, has been shown to be effective as an antiemetic after chemotherapy
T S Hahm et al.
Anaesthesia, 65(5), 500-504 (2010-03-27)
We compared the prophylactic anti-emetic efficacy of ramosetron, a newly developed 5-HT(3) antagonist, and ondansetron in patients at high-risk for postoperative nausea and vomiting after total knee replacement. Eighty-four patients with three risk factors for postoperative nausea and vomiting (female
Eun Young Park et al.
The Journal of international medical research, 41(3), 654-663 (2013-05-11)
This randomized, double-blind study compared the antiemetic efficacy of ramosetron with that of ramosetron combined with midazolam, and investigated whether the timing of midazolam administration affected the incidence of postoperative nausea and vomiting (PONV). Nonsmoking female patients undergoing laparoscopic gynaecological
Maulana M Ansari et al.
Indian journal of medical sciences, 64(6), 272-280 (2010-06-01)
Post-operative nausea and vomiting (PONV) is common. 5HT 3 receptor antagonists are commonly used drugs for its prevention. A study was designed to compare the efficacy and safety of ramosetron and ondansetron in patients undergoing laparoscopic cholecystectomy (lap chole). A
Serotonin 5-HT3 receptor antagonist for treatment of severe diabetic diarrhea.
Satoshi Murao et al.
Diabetes care, 33(3), e38-e38 (2010-03-02)
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