SML0674
雷莫司琼 盐酸盐
≥98% (HPLC), 5-HT3 receptor antagonist, powder
别名:
(R)-5-[(1-Methyl-3-indolyl)carbonyl]-4,5,6,7-tetrahydro-1H-benzimidazole hydrochloride, YM-060, YM060
产品名称
雷莫司琼 盐酸盐, ≥98% (HPLC)
SMILES string
Cl.[n]1(c2c(c(c1)C(=O)[C@@H]3CCc4nc[nH]c4C3)cccc2)C
InChI
1S/C17H17N3O.ClH/c1-20-9-13(12-4-2-3-5-16(12)20)17(21)11-6-7-14-15(8-11)19-10-18-14;/h2-5,9-11H,6-8H2,1H3,(H,18,19);1H/t11-;/m1./s1
InChI key
XIXYTCLDXQRHJO-RFVHGSKJSA-N
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D -36 to -46°, c = 1 in methanol
storage condition
desiccated
color
white to beige
solubility
H2O: 20 mg/mL, clear
storage temp.
−20°C
Quality Level
相关类别
Biochem/physiol Actions
Ramosetron hydrochloride is a potent serotonin 5-HT3 receptor antagonist with higher afinity for the 5-HT3 receptor than other currently available antagonists.
Ramosetron hydrochloride is a potent serotonin 5-HT3 receptor antagonist with higher afinity for the 5-HT3 receptor than other currently available antagonists. Ramosetron is used clinically both as an antiemetic to treat nausea and vomiting following chemotherapy or after surgery, and in treatment of irritable bowel syndrome.
Ramosetron is a tetra hydrobenzimidazole derivative, containing an indole ring. It inhibits colon contraction mediated by serotonin, competitively.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
D K Choi et al.
Acta anaesthesiologica Scandinavica, 54(8), 962-969 (2010-07-16)
The aim of this study was to evaluate the efficacy of ondansetron and ramosetron in the reduction of post-operative nausea and vomiting (PONV) associated with patient-controlled analgesia (PCA) after cardiac surgery. A total of 320 patients scheduled for elective cardiac
Postoperative Nausea and Vomiting, 58-58 (2016)
A new antiemetic ramosetron hydrochloride
Tsukagoshi S
Gan to Kagaku Ryoho. Cancer & Chemotherapy, 24(3), 371-380 (2016)
Hyo-Jin Byon et al.
European journal of anaesthesiology, 29(4), 192-196 (2012-01-26)
Postoperative nausea and vomiting remains a clinically important problem after strabismus surgery in children. To study the benefit of adding midazolam to ramosetron on the incidence of postoperative nausea, retching or vomiting and on the incidence of postoperative agitation. A
Yoshitaka Fujii
Current drug safety, 6(2), 122-127 (2011-03-09)
Postoperative nausea and vomiting (PONV) are distressing and frequent adverse events of anesthesia and surgery. Serotonin receptor antagonists (SRAs), including ondansetron, granisetron, tropisetron, dolasetron, and ramosetron, effectively decrease the incidence of PONV. Among these SRAs, ramosetron is the most effective
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