SML0681
Febrifugine dihydrochloride
≥95% (HPLC)
别名:
3-[3-[(2R,3S)-3-Hydroxy-2-piperidinyl]-2-oxopropyl]-4(3H)-quinazolinone dihydrochloride
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关于此项目
经验公式（希尔记法）:
C16H19N3O3 · 2HCl
化学文摘社编号:
分子量:
374.26
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
SMILES string
O=C1C2=CC=CC=C2N=CN1CC(C[C@@H]3[C@@H](O)CCCC3)=O.C
InChI
1S/C17H20N2O3.CH4/c20-13(9-12-5-1-4-8-16(12)21)10-19-11-18-15-7-3-2-6-14(15)17(19)22;/h2-3,6-7,11-12,16,21H,1,4-5,8-10H2;1H4/t12-,16+;/m1./s1
InChI key
SNTOTCUGCWLHEZ-KKJWGQAZSA-N
assay
≥95% (HPLC)
form
powder
optical activity
[α]/D 10 to 15°, c = 1 in H2O
storage condition
desiccated
color
off-white to gray-brown
solubility
H2O: 15 mg/mL, clear
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Febrifugine dihydrochloride exhibits strong antimalarial activity against Plasmodium falciparum, the most insidious malaria causative agent. The adverse effects of febrifugine include diarrhoea, vomiting and liver toxicity.
Febrifugine is an antimalarial, the active component of the Chinese herb Chang Shan. Recent studies indicate that its mechanism of action is as an inhibitor of prolyl-transfer RNA synthetase (ProRS).
Febrifugine is an antimalarial, the active component of the Chinese herb Chang Shan; inhibitor of prolyl-transfer RNA synthetase (ProRS).
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
The chemistry and biology of febrifugine and halofuginone.
McLaughlin N P, et al.
Bioorganic & Medicinal Chemistry, 22(7), 1993-2004 (2014)
商品
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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