SML0690
L-161,982
≥98% (HPLC)
别名:
N-[[4′-[[3-丁基-1,5-二氢-5-氧-1-[2-(三氟甲基)苯基] -4H-1,2,4-三唑-4-基]甲基] [1,1”-联苯基] -2-基]磺酰基] -3-甲基-2-噻吩甲酰胺
SMILES string
FC(F)(F)c1c(cccc1)[n]2nc([n]([c]2=O)Cc3ccc(cc3)c4c(cccc4)[S](=O)(=O)NC(=O)c5[s]ccc5C)CCCC
InChI
1S/C32H29F3N4O4S2/c1-3-4-13-28-36-39(26-11-7-6-10-25(26)32(33,34)35)31(41)38(28)20-22-14-16-23(17-15-22)24-9-5-8-12-27(24)45(42,43)37-30(40)29-21(2)18-19-44-29/h5-12,14-19H,3-4,13,20H2,1-2H3,(H,37,40)
InChI key
MMDNKTXNUZFVKD-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 15 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
L-161,982是一种有效的EP4受体拮抗剂。
L-161,982是一种有效的EP4受体拮抗剂，对前列腺素受体家族的所有其他成员具有选择性（对于人EP4、TP、EP3、DP、FP、IP、EP1和EP2受体的Ki值分别为0.024、0.71、1.90、5.10、5.63、6.74、19和23μM） 。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Michael B Geary et al.
PloS one, 10(8), e0136351-e0136351 (2015-08-28)
Flexor tendon injuries are a common clinical problem, and repairs are frequently complicated by post-operative adhesions forming between the tendon and surrounding soft tissue. Prostaglandin E2 and the EP4 receptor have been implicated in this process following tendon injury; thus
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