SML0693
LY-333531 盐酸盐
≥98% (HPLC)
别名:
(9S)-9-[(二甲氨基)甲基] -6,7,10,11-四氢-9H,18H-5,21:12,17-二甲基二苯并[e,k]吡咯并[3,4-h] [ 1,4,13]草二氮杂环十六烷-18,20(19H)-二酮 盐酸盐, 芦丁黄素
产品名称
LY-333531 盐酸盐, ≥98% (HPLC)
SMILES string
Cl.[n]21c3c(c(c2)C4=C(c5c6c([n](c5)CC[C@H](OCC1)CN(C)C)cccc6)C(=O)NC4=O)cccc3
InChI
1S/C28H28N4O3.ClH/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24;/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34);1H/t18-;/m0./s1
InChI key
NYQIEYDJYFVLPO-FERBBOLQSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
protect from light
color
orange-red
solubility
DMSO: 10 mg/mL, clear
storage temp.
−20°C
Quality Level
相关类别
Application
LY-333531盐酸盐/ruboxistaurin已被用作PKCB阻断剂，以比较来源于受刺激的野生型细胞的磷酸肽与来源于PKCB敲除细胞或野生型细胞的磷酸肽。
Biochem/physiol Actions
LY333531是一种有效的PKCβ特异性抑制剂。
LY333531是蛋白激酶Cβ（PKCβ； PKCβ1和PKCβ2的IC50值分别为4.7和5.9 nM）的一种有效抑制剂。PKCβ亚型在氧化应激状态下过表达，尤其是与糖尿病有关。在糖尿病大鼠中，LY333531可改善视网膜的血流量和白细胞截留，并防止心肌肥大和心脏功能障碍。
General description
LY-333531盐酸盐也被称为ruboxistaurin。
Other Notes
光敏感
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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