SML0716
SB225002
≥98% (HPLC), chemokine receptor CXCR2 inhibitor, powder
别名:
N-(2-羟基-4-硝基苯基)-N′-(2-溴苯基)脲, SB-225002
产品名称
SB225002, ≥98% (HPLC)
SMILES string
Brc1c(cccc1)NC(=O)Nc2c(cc(cc2)[N+](=O)[O-])O
InChI
1S/C13H10BrN3O4/c14-9-3-1-2-4-10(9)15-13(19)16-11-6-5-8(17(20)21)7-12(11)18/h1-7,18H,(H2,15,16,19)
InChI key
MQBZVUNNWUIPMK-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
room temp
Quality Level
Biochem/physiol Actions
SB-225002 对 CXCR2（白细胞介素 8 受体 β）的阻断作用，阻止 IL-8 诱导从中性粒细胞释放基质金属蛋白酶-9。基质金属蛋白酶-9 是与炎症相关的蛋白水解酶。
SB-225002 是趋化因子受体 CXCR2 的有效非肽抑制剂。
SB-225002 是趋化因子受体 CXCR2 的有效非肽抑制剂，IC50 为 22 nM，用于抑制白细胞介素 IL-8 与 CXCR2 的结合，对 CXCR1 受体的选择性 > 150 倍。CXCR2 结合许多不同的免疫细胞化学引诱物。SB-225002 对于癌症发展至关重要，并且与慢性阻塞性肺病、类风湿性关节炎和溃疡性结肠炎等炎性疾病有关。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulation of matrix metalloproteinase-9 release from IL-8-stimulated human neutrophils.
Chakrabarti S and Patel K D
Journal of Leukocyte Biology, 78(1), 279-288 (2005)
Dong Cui et al.
Cancer biology & therapy, 20(5), 608-616 (2018-11-09)
C-X-C motif chemokine ligand 5 (CXCL5) is initially identified to recruit neutrophils by interacting with its receptor, C-X-C motif chemokine receptor 2 (CXCR2). Our prior work demonstrated that the expression levels of CXCL5 and CXCR2 were higher in the papillary
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