SML0720
醋甲唑胺
≥98% (HPLC), carbonic anhydrase inhibitor, powder
别名:
N-(4-甲基-2-氨基磺酰基-Δ2-1,3,4-噻二唑-5-亚基)乙酰胺
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关于此项目
经验公式（希尔记法）:
C5H8N4O3S2
化学文摘社编号:
分子量:
236.27
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
209-066-7
MDL number:
产品名称
醋甲唑胺, ≥98% (HPLC)
InChI
1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12)/b7-4+
InChI key
FLOSMHQXBMRNHR-QPJJXVBHSA-N
SMILES string
CN1N=C(S\C1=N\C(C)=O)S(N)(=O)=O
assay
≥98% (HPLC)
form
powder
storage condition
protect from light
color
white to beige
mp
208 °C (dec.) (lit.)
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
Quality Level
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Biochem/physiol Actions
Cell-permeable and potent carbonic anhydrase (CA) inhibitor
Methazolamide has a plasma half-life of 14 hours in humans. Methazolamide has relatively good lipid solubility and low plasma protein binding ability. Thus, it diffuses into tissues and fluids much more readily than acetazolamide, another carbonic anhydrase inhibitor. Methazolamide has less side effects than acetazolamide.
Methazolamide is a cell-permeable and potent carbonic anhydrase (CA) inhibitor that is used in the treatment of glaucoma. Methazolamide is an insulin sensitizer that reduces hepatic glucose generation in animal models.
Other Notes
Light sensitive
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
The pharmacology of methazolamide in relation to the treatment of glaucoma.
Maren TH, et al.
Investigative Ophthalmology & Visual Science, 16(8), 730-742 (1977)
Ming-Tao Yang et al.
Psychopharmacology, 232(20), 3763-3772 (2015-08-01)
Dysregulation of noradrenergic and dopaminergic systems is involved in the pathology of attention deficit hyperactivity disorder (ADHD). Carbonic anhydrase (CA) has been reported to affect monoamine transmission in the central nervous system. The aim of this study is to investigate
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