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SML0720

醋甲唑胺

Name: 醋甲唑胺
Brand: SIGMA

≥98% (HPLC), carbonic anhydrase inhibitor, powder

别名:

N-(4-甲基-2-氨基磺酰基-Δ²-1,3,4-噻二唑-5-亚基)乙酰胺

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关于此项目

经验公式（希尔记法）:

C₅H₈N₄O₃S₂

化学文摘社编号:

554-57-4

分子量:

236.27

NACRES:

NA.77

PubChem Substance ID:

329825590

UNSPSC Code:

12352200

EC Number:

209-066-7

MDL number:

MFCD00083416

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

protect from light

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产品名称

醋甲唑胺, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

white to beige

mp

208 °C (dec.) (lit.)

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

CN1N=C(S\C1=N\C(C)=O)S(N)(=O)=O

InChI

1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12)/b7-4+

InChI key

FLOSMHQXBMRNHR-QPJJXVBHSA-N

Gene Information

human ... CA1(759), CA2(760), CA4(762), CA7(766)

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Biochem/physiol Actions

Methazolamide has a plasma half-life of 14 hours in humans. Methazolamide has relatively good lipid solubility and low plasma protein binding ability. Thus, it diffuses into tissues and fluids much more readily than acetazolamide, another carbonic anhydrase inhibitor. Methazolamide has less side effects than acetazolamide.

Cell-permeable and potent carbonic anhydrase (CA) inhibitor

Methazolamide is a cell-permeable and potent carbonic anhydrase (CA) inhibitor that is used in the treatment of glaucoma. Methazolamide is an insulin sensitizer that reduces hepatic glucose generation in animal models.

Other Notes

Light sensitive

pictograms

GHS08,GHS07

signalword

Warning

hcodes

H302 + H312 + H332,H351

pcodes

P202 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2

存储类别

11 - Combustible Solids

wgk

WGK 3

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000447717

0000365542

0000152502

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The pharmacology of methazolamide in relation to the treatment of glaucoma.

Maren TH, et al.

Investigative Ophthalmology & Visual Science, 16(8), 730-742 (1977)

Inhibition of hyperactivity and impulsivity by carbonic anhydrase inhibitors in spontaneously hypertensive rats, an animal model of ADHD.

Ming-Tao Yang et al.

Psychopharmacology, 232(20), 3763-3772 (2015-08-01)

Dysregulation of noradrenergic and dopaminergic systems is involved in the pathology of attention deficit hyperactivity disorder (ADHD). Carbonic anhydrase (CA) has been reported to affect monoamine transmission in the central nervous system. The aim of this study is to investigate

全球贸易项目编号

货号	GTIN
SML0720-50MG	04061832723839

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