醋甲唑胺

Name: 醋甲唑胺
Brand: SIGMA

≥98% (HPLC)

别名:

N-(4-甲基-2-氨基磺酰基-Δ²-1,3,4-噻二唑-5-亚基)乙酰胺

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About This Item

经验公式（希尔记法）:

C₅H₈N₄O₃S₂

CAS Number:

554-57-4

分子量:

236.27

EC 号:

209-066-7

MDL编号:

MFCD00083416

UNSPSC代码:

12352200

PubChem化学物质编号:

329825590

NACRES:

NA.77

方案

≥98% (HPLC)

表单

powder

储存条件

protect from light

颜色

white to beige

mp

208 °C (dec.) (lit.)

溶解性

DMSO: 20 mg/mL, clear

储存温度

2-8°C

SMILES字符串

CN1N=C(S\C1=N\C(C)=O)S(N)(=O)=O

InChI

1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12)/b7-4+

InChI key

FLOSMHQXBMRNHR-QPJJXVBHSA-N

基因信息

human ... CA1(759), CA2(760), CA4(762), CA7(766)

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生化/生理作用

Cell-permeable and potent carbonic anhydrase (CA) inhibitor

Methazolamide has a plasma half-life of 14 hours in humans. Methazolamide has relatively good lipid solubility and low plasma protein binding ability. Thus, it diffuses into tissues and fluids much more readily than acetazolamide, another carbonic anhydrase inhibitor. Methazolamide has less side effects than acetazolamide.

Methazolamide is a cell-permeable and potent carbonic anhydrase (CA) inhibitor that is used in the treatment of glaucoma. Methazolamide is an insulin sensitizer that reduces hepatic glucose generation in animal models.