SML0724
比卡维林
from Fusarium subglutinans, ≥98% (HPLC)
别名:
6,11-Dihydroxy-3,8-dimethoxy-1-methylbenzo[b]xanthene-7,10, 12-trione, Lycopersin, NSC 215139
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关于此项目
biological source
Fusarium subglutinans
Quality Level
assay
≥98% (HPLC)
form
powder
solubility
DMSO: 0.5 mg/mL (may require sonication and heating), chloroform: 0.5 mg/mL, dichloromethane: 0.5 mg/mL
storage temp.
−20°C
SMILES string
[o]1c2c([c](c4c1cc(cc4C)OC)=O)c(c3c(c2O)C(=O)C(=CC3=O)OC)O
InChI
1S/C20H14O8/c1-7-4-8(26-2)5-10-12(7)17(23)15-18(24)13-9(21)6-11(27-3)16(22)14(13)19(25)20(15)28-10/h4-6,24-25H,1-3H3
InChI key
ZOQMSOSJEWBMHP-UHFFFAOYSA-N
Biochem/physiol Actions
Bikaverin is a red pigment with a polyketide tetracyclic benzoxanthone structure. Bikaverin has an antibiotic activity against some protozoa and fungi and also inhibits Succinate- and NAD-linked respiration in rat mitochondria at 20 mg/mL. At higher concentrations (50 mg/mL) it acts as an oxidative phosphorylation uncoupling agent of tumor cells and isolated rat liver mitochondria. Bikaverin demonstrates antitumor activity on Erlich ascites carcinoma (EAC), leukemia and sarcoma cells.
Bikaverin is a red pigment with a polyketide tetracyclic benzoxanthone structure. Bikaverin has an antibiotic activity against some protozoa and fungi.
Preparation Note
Soluble in DMSO (0.5 mg/mL, may require sonication and heating). For further dilution, water based solutions can be used. Chloroform (0.5 mg/mL) and dichloromethane (0.5 mg/mL).
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Pia Linnemannstöns et al.
Fungal genetics and biology : FG & B, 37(2), 134-148 (2002-11-01)
The ascomycete Gibberella fujikuroi mating population C (MP-C) is well known for the production of gibberellins, but also produces many other secondary metabolites, including the red polyketide pigment bikaverin. Here, we used a differential display method to clone a polyketide
W Giordano et al.
FEMS microbiology letters, 180(1), 111-116 (1999-11-05)
Gibberellins, fatty acids and the polyketides bikaverin and fusarin C are synthesized from a common precursor, acetyl-CoA. The production of these compounds in Gibberella fujikuroi was strongly influenced by aeration, determined by the air/medium ratio in shaken batch cultures. Higher
Enzymatic synthesis of aromatic polyketides using PKS4 from Gibberella fujikuroi.
Suzanne M Ma et al.
Journal of the American Chemical Society, 129(35), 10642-10643 (2007-08-19)
Gábor Kohut et al.
Journal of basic microbiology, 50(1), 59-71 (2010-01-19)
A homologue of the adenylyl cyclase (AC) gene of Neurospora crassa, named Fpacy1 was cloned from the genomic library of Fusarium proliferatum ITEM 2287 by screening the library with a DNA fragment amplified by using PCR primers designed from conserved
Takayoshi Saruwatari et al.
The Journal of antibiotics, 64(1), 9-17 (2010-11-26)
Fungal polyketide synthases (PKSs) catalyze a carbon-carbon bond forming reaction in an iterative manner using a variety of acyl-CoA molecules as substrates when biosynthesizing complex polyketides. Although most members from this class of natural products exhibit notable biological activities, often
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML0724-1MG | 04061837101366 |
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