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Merck
CN

SML0741

Sigma-Aldrich

ML324

≥98% (HPLC)

别名:

N-(3-(Dimethylamino)propyl)-4-(8-hydroxyquinolin-6-yl)benzamide

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关于此项目

经验公式（希尔记法）:
C21H23N3O2
CAS Number:
1222800-79-4
分子量:
349.43
MDL编号:
MFCD28053518
UNSPSC代码:
12352200
PubChem化学物质编号:
329825592
NACRES:
NA.77

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质量水平

100

方案

≥98% (HPLC)

表单

powder

储存条件

desiccated

颜色

white to light brown

溶解性

DMSO: 10 mg/mL, clear

储存温度

2-8°C

SMILES字符串

CN(C)CCCNC(C1=CC=C(C2=CC(O)=C(N=CC=C3)C3=C2)C=C1)=O

InChI

1S/C21H23N3O2/c1-24(2)12-4-11-23-21(26)16-8-6-15(7-9-16)18-13-17-5-3-10-22-20(17)19(25)14-18/h3,5-10,13-14,25H,4,11-12H2,1-2H3,(H,23,26)

InChI key

QDBVSOZTVKXUES-UHFFFAOYSA-N

相关类别

生化/生理作用

ML324 is a potent JMJD2 demethylase inhibitor that is highly effective in reducing herpes simplex virus (HSV) IE gene expression. ML324 potently blocks the initiation of viral lytic infection and HSV-1 reactivation in the sensory ganglia of latently infected mice.
ML324 is a potent JMJD2 demethylase inhibitor.

特点和优势

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000151444
0000151443
0000151443
0000151444
0000149030

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David M Carter et al.
SLAS discovery : advancing life sciences R & D, 22(7), 801-812 (2017-03-28)
Human lysine demethylase (KDM) enzymes (KDM1-7) constitute an emerging class of therapeutic targets, with activities that support growth and development of metastatic disease. By interacting with and co-activating the androgen receptor, the KDM4 subfamily (KDM4A-E) promotes aggressive phenotypes of prostate
Salil Saurav Pathak et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 42(4), 854-863 (2016-10-27)
Major depressive disorder (MDD) is debilitating mental illness and is one of the leading contributors to global burden of disease, but unfortunately newer and better drugs are not forthcoming. The reason is lack of complete understanding of molecular mechanisms underlying
Robert Kleszcz et al.
Cellular oncology (Dordrecht), 42(4), 505-520 (2019-05-16)
Activation of the Wnt pathway contributes to the development of head and neck squamous cell carcinomas (HNSCC) and its inhibition has recently emerged as a promising therapeutic strategy. Here, we aimed at identifying suitable molecular targets for down-regulation of canonical
Lei Duan et al.
Oncogene, 38(28), 5643-5657 (2019-04-11)
Platinum-based drugs such as cisplatin (CP) are the first-line chemotherapy for non-small-cell lung carcinoma (NSCLC). Unfortunately, NSCLC has a low response rate to CP and acquired resistance always occurs. Histone methylation regulates chromatin structure and is implicated in DNA repair.
Grzegorz Dobrynin et al.
Scientific reports, 7(1), 11094-11094 (2017-09-13)
Regions of hypoxia (low oxygen) occur in most solid tumours and cells in these areas are the most aggressive and therapy resistant. In response to decreased oxygen, extensive changes in gene expression mediated by Hypoxia-Inducible Factors (HIFs) contribute significantly to
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