SML0742
EUK-8
≥95% (HPLC)
别名:
(SP-5-13)-Chloro[[2,2′-[1,2-ethanediylbis(nitrilomethylidyne)]bis[phenolato]](2-)-N,N′,O,O′]-manganese, (Salen)manganese(III) chloride, Chloro(bis(salicylidene)ethylenediamine)manganese, Chloro[N,N′-ethylenebis(salicylideneaminato)]manganese, EUK 8, Manganese(salen) chloride
质量水平
方案
≥95% (HPLC)
表单
powder
储存条件
desiccated
颜色
, faint to very dark brown
溶解性
H2O: 1 mg/mL, clear
储存温度
−20°C
SMILES字符串
[Mn]1(Oc2c(cccc2)C=NCCN=Cc3c(cccc3)O1)Cl
InChI
1S/C16H16N2O2.ClH.Mn/c19-15-7-3-1-5-13(15)11-17-9-10-18-12-14-6-2-4-8-16(14)20;;/h1-8,11-12,19-20H,9-10H2;1H;/q;;+3/p-3
InChI key
HBQGFROGWOHBAG-UHFFFAOYSA-K
生化/生理作用
EUK-8 is a salen manganese complex that exhibit potent antioxidant activities.
EUK-8 is a salen manganese complex that exhibit potent antioxidant activities. EUK-8 is a superoxide dismutase (SOD) that inhibits amyloid fibril formation, including islet amyloid polypeptide (IAPP), β-amyloid and lysozyme amyloid aggregation. It appears that EUK-8 disrupts the pre-formed amyloid fibrils. EUK-8 increases the viability of the SK-N-MC cells exposed to preformed IAPP fibrils.
其他说明
air sensitive
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Jiquan Zhao et al.
Carbohydrate research, 344(1), 61-66 (2008-11-11)
Several chiral Schiff-base ligands with sugar moieties at C-3 (3') or C-5 (5') of salicylaldehyde were synthesized from reaction of salicylaldehyde derivatives with diamine. These ligands coordinated with Mn(III) to afford the corresponding chiral salen-Mn(III) complexes characterized by FT-IR, MS
Yoritada Watanabe et al.
Chemical communications (Cambridge, England), (47)(47), 4958-4960 (2006-12-01)
A new Mn(Salen) complex bearing an ureido group as an auxiliary that is three-dimensionally fixed by a cyclopentane ring fused to the Salen structure was developed. This compound exhibited considerably higher catalase-like activity than the original Mn(Salen), i.e., the cyclopentane-fused
Rosalind A Rosenthal et al.
Anti-cancer agents in medicinal chemistry, 11(4), 359-372 (2011-04-02)
Salen Mn complexes, including EUK-134, EUK-189 and a newer cyclized analog EUK-207, are synthetic SOD/catalase mimetics that have beneficial effects in many models of oxidative stress. As oxidative stress is implicated in some forms of delayed radiation injury, we are
Filip Matthijssens et al.
Free radical biology & medicine, 45(5), 708-715 (2008-06-25)
Numerous studies have aimed to alleviate oxidative stress in a wide range of organisms by increasing superoxide dismutase (SOD) activity. However, experimental approaches have yielded contradictory evidence, and kinetics models have shown that increases in SOD activity may increase, decrease
Mitochondrial protection and the reversal of left ventricular remodeling.
Motoaki Sano
Circulation journal : official journal of the Japanese Circulation Society, 73(11), 2017-2018 (2009-10-24)
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