SML0743
EUK-134
≥95% (HPLC), amyloid fibril formation blocker, powder
别名:
(SP-5-13)-氯[[2,2′-[1,2-乙二基双[（腈-?N）亚甲基]]双[6-甲氧基苯酚-KO]](2-)]-锰, 2,2′-[1,2-乙二基双（亚硝甲基亚炔基）]双[6-甲氧基-苯酚锰配合物, EUK 134, 氯[[2,2′-[1,2-乙二基双(亚硝基甲基二炔)]双[6-甲氧基苯酚基]](2-)-N2,N2′,O1,O1′]锰
产品名称
EUK-134, ≥95% (HPLC)
SMILES string
[Mn+2]Cl.N(=Cc2c(c(ccc2)OC)[O-])CCN=Cc1c(c(ccc1)OC)[O-]
InChI
1S/C18H20N2O4.ClH.Mn/c1-23-15-7-3-5-13(17(15)21)11-19-9-10-20-12-14-6-4-8-16(24-2)18(14)22;;/h3-8,11-12,21-22H,9-10H2,1-2H3;1H;/q;;+3/p-3
InChI key
YUZJJFWCXJDFOQ-UHFFFAOYSA-K
assay
≥95% (HPLC)
form
powder
storage condition
desiccated
color
, faint to very dark brown
solubility
H2O: 2 mg/mL, clear (warmed)
storage temp.
−20°C
Quality Level
相关类别
Application
EUK-134已被用于确定人主动脉内皮细胞（HAEC）中缺氧诱导因子-1α (HIF-1α)稳定的机制。
EUK-134已被用作抗氧化剂。
Biochem/physiol Actions
EUK-134是一种锰-salen衍生物，具有很强的抗氧化活性。 EUK-134是一种超氧化物歧化酶（SOD），可抑制淀粉样蛋白原纤维形成，包括胰岛淀粉样蛋白多肽（IAPP）、β-淀粉样蛋白和溶菌酶淀粉样蛋白聚集。EUK-134可破坏预先形成的淀粉样蛋白原纤维。EUK-134可提高暴露于预成型IAPP原纤维的SK-N-MC细胞的活力。
EUK-134是一种锰-salen衍生物，具有很强的抗氧化活性，可抑制淀粉样蛋白原纤维形成。
Other Notes
空气敏感
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
HIF-1α is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium.
Wu D, et al.
eLife, 6, e25217-e25217 (2017)
Anna K Stovall et al.
Frontiers in fungal biology, 2 (2021-10-09)
The fungal pathogen Cryptococcus neoformans relies on post-transcriptional mechanisms of gene regulation to adapt to stressors it encounters in the human host, such as oxidative stress and nutrient limitation. The kinase Gcn2 regulates translation in response to stress by phosphorylating
Cory L Simpson et al.
Cell reports, 34(5), 108689-108689 (2021-02-04)
The epidermis regenerates continually to maintain a protective barrier at the body's surface composed of differentiating keratinocytes. Maturation of this stratified tissue requires that keratinocytes undergo wholesale organelle degradation upon reaching the outermost tissue layers to form compacted, anucleate cells.
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