SML0745
NS6180
≥98% (HPLC)
别名:
4-[[3-(Trifluoromethyl)phenyl]methyl]-2H-1,4-benzothiazin-3(4H)-one
SMILES string
FC(F)(F)c1cc(ccc1)CN2c3c(cccc3)SCC2=O
InChI
1S/C16H12F3NOS/c17-16(18,19)12-5-3-4-11(8-12)9-20-13-6-1-2-7-14(13)22-10-15(20)21/h1-8H,9-10H2
InChI key
ZUIJXKLTUFCDGO-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
Quality Level
相关类别
Biochem/physiol Actions
NS6180 is a novel inhibitor of the intermediate-conductance Ca2+-activated K+ channel (KCa3.1) The IC50 of NS6180 against cloned human KCa3.1 is 9 nM. The compound blocks proliferation and production of IL-2 and IFNγ with sub-micromolar potencies in either ConA or PMA/ionomycin challenged rat splenocytes.
NS6180 is a novel inhibitor of the intermediate-conductance Ca2+-activated K+ channel (KCa3.1).
signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 2 - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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