SML0756
IDT307
≥98% (HPLC), DAT, NET and SERT substrate, powder
别名:
4-(4-Dimethylamino)phenyl-1-methylpyridinium iodide, 4-[p-(Dimethylamino)phenyl]-1-methylpyridinium iodide, APP+
产品名称
IDT307, ≥98% (HPLC)
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
, orange to dark orange-red
溶解性
DMSO: 15 mg/mL, clear
储存温度
−20°C
SMILES字符串
[I-].[n+]1(ccc(cc1)c2ccc(cc2)N(C)C)C
InChI
1S/C14H17N2.HI/c1-15(2)14-6-4-12(5-7-14)13-8-10-16(3)11-9-13;/h4-11H,1-3H3;1H/q+1;/p-1
InChI key
CAMWVBRDIKKGII-UHFFFAOYSA-M
相关类别
生化/生理作用
IDT307 (APP+) is a fluorescent analogue of the dopaminergic neurotoxin MPP+ monoamine transporter substrate that fluoresces after uptake into cells. IDT307 is a substrate for the dopamine transporter (DAT), norepinephrine transporter (NET), and serotonin transporter (SERT). IDT307 (APP+) was found to label catecholamine neuronal cell bodies with high selectivity in midbrain and was used to investigate SERT function in lymphocytes and platelets.
IDT307 (APP+) is a fluorescent analogue of the dopaminergic neurotoxin MPP+.
特点和优势
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
警示用语：
Danger
危险声明
危险分类
Acute Tox. 2 Oral
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
M Engevik et al.
Beneficial microbes, 12(6), 583-599 (2021-09-23)
The serotonin transporter (SERT) readily takes up serotonin (5-HT), thereby regulating the availability of 5-HT within the intestine. In the absence of SERT, 5-HT remains in the interstitial space and has the potential to aberrantly activate the many 5-HT receptors
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