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Merck
CN

SML0761

棉酚

≥90% (HPLC)

别名:

2-(3,4-二羟基苯)-8-(β-D-吡喃葡萄糖基氧基)-3,5,7-三羟基-4H-1-苯并吡喃-4-酮, 3,3′,4′,5,7,8-六羟基黄酮8-葡萄糖苷, 棉花皮素-8-葡萄糖甙

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关于此项目

经验公式（希尔记法）:
C21H20O13
化学文摘社编号:
652-78-8
分子量:
480.38
NACRES:
NA.77
PubChem Substance ID:
329825593
UNSPSC Code:
12352200
MDL number:
MFCD00017429
Assay:
≥90% (HPLC)
Form:
powder
Storage condition:
desiccated

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InChI

1S/C21H20O13/c22-5-11-13(27)15(29)17(31)21(32-11)34-19-10(26)4-9(25)12-14(28)16(30)18(33-20(12)19)6-1-2-7(23)8(24)3-6/h1-4,11,13,15,17,21-27,29-31H,5H2/t11-,13-,15+,17-,21+/m1/s1

SMILES string

OC[C@H]1O[C@@H](Oc2c(O)cc(O)c3C(=O)C(O)=C(Oc23)c4ccc(O)c(O)c4)[C@H](O)[C@@H](O)[C@@H]1O

InChI key

SJRXVLUZMMDCNG-KKPQBLLMSA-N

biological source

Hibiscus vitifolius

assay

≥90% (HPLC)

form

powder

storage condition

desiccated

color

, light yellow to dark green-yellow

solubility

DMSO: 15 mg/mL, clear

storage temp.

−20°C

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General description

棉纤维素具有抗炎特性。它抑制半乳糖诱导的白内障形成，并降低β淀粉样蛋白诱导的毒性。 棉纤维素对于四氯化碳诱导的毒性和双（2-氯乙基）硫化物诱导的皮肤毒性具有保护作用。它还诱导骨髓瘤细胞凋亡。棉纤维素具有抗惊厥作用。

Biochem/physiol Actions

棉酚是一种从木槿中分离出来的消炎性五羟基黄酮葡萄糖苷，可用作治疗糖尿病、黄疸和炎症的草药。棉酚可有效抑制人类癌细胞的增殖，包括黑色素瘤和神经胶质瘤细胞。棉酚蛋白能够直接结合并抑制BRAFV600E和CDK4激酶，并调节U251胶质瘤细胞中的Chk1和Cdc25C。
棉酚是一种消炎性五羟基黄酮葡萄糖苷，可直接结合并抑制BRAFV600E和CDK4激酶。

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number
0000122827
0000121694
0000085333
0000075211
0000042787

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