assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 15 mg/mL, clear
storage temp.
2-8°C
Quality Level
相关类别
Biochem/physiol Actions
SR1555是一种选择性 RORγ 反向激动剂，能够抑制TH17细胞的发育和功能，这种细胞是一种T细胞亚群，已被证明参与多发性硬化症和类风湿性关节炎等多种自身免疫性疾病的病理过程。SR1555还能够提高T调节细胞的频率，这种作用尚未在之前描述的RORγ配体中被发现。
SR1555是一种选择性 RORγ 反向激动剂。
hcodes
pcodes
Hazard Classifications
Aquatic Chronic 4
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
M-H Haddadi et al.
Clinical and experimental immunology, 201(2), 205-221 (2020-05-14)
Regulatory T (Treg ) cell therapy is a promising approach for immune tolerance induction in autoimmunity conditions and cell/organ transplantations. Insufficient isolation yields and impurity during downstream processes and Treg instability after adoptive transfer in inflammatory conditions are major limitations
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