SML0772
Curvularin
from Penicillium citrinum, ≥98% (HPLC)
别名:
2H-3-Benzoxacyclododecin-2,10(1H)-dione, 4,5,6,7,8,9-hexahydro-11,13-dihydroxy-4-methyl-,(4S)-
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关于此项目
经验公式（希尔记法）:
C16H20O5
化学文摘社编号:
分子量:
292.33
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
biological source
Penicillium citrinum
Quality Level
assay
≥98% (HPLC)
form
powder
solubility
DMSO: 1 mg/mL
storage temp.
−20°C
SMILES string
OC1=C(C(CCCCC[C@H](C)O2)=O)C(CC2=O)=CC(O)=C1
InChI
1S/C16H20O5/c1-10-5-3-2-4-6-13(18)16-11(8-15(20)21-10)7-12(17)9-14(16)19/h7,9-10,17,19H,2-6,8H2,1H3/t10-/m0/s1
InChI key
VDUIGYAPSXCJFC-JTQLQIEISA-N
Biochem/physiol Actions
S - Curvularin is a macrocyclic lactone with cytotoxic activity. Curvularin inhibits cell division as well as expression of human inducible nitric oxide synthase (iNOS), an enzyme critically involved in pro-inflammatory immune processes. Curvularin anti-inflammatory activity was demonstrated in chronic inflammatory disease models in mice such as Chronic Induced Arthritis (CIA) as well as in human alveolar epithelial A549/8 cells.
Curvularin is a macrocyclic lactone with cytotoxic activity.
Preparation Note
Soluble in DMSO (1 mg/mL), Chloroform (3 mg/mL) and Dichloromethane (3 mg/mL). Note: Insoluble in water.
Other Notes
Store the product sealed at −20 °C. Under these conditions the product is stable for at least 5 years.
相关内容
Instructions
Lian Wu Xie et al.
Applied biochemistry and biotechnology, 159(1), 284-293 (2009-04-01)
With the anti-microbial and anti-tumor composite screening model, bioassay-guided fractionation led to the isolation of two structurally related bioactive compounds, curvularin and alphabeta-dehydrocurvularin, from ethyl acetate extract of Eupenicillium sp. associated with marine sponge Axinella sp. Further study on the
Birgitte Andersen et al.
International journal of food microbiology, 126(1-2), 172-179 (2008-07-05)
Ulocladium, which is phylogenetically related to Alternaria, contains species that are food spoilers and plant pathogens, but also species that have potential as enzyme producers and bio-control agents. Ulocladium spp. are often found on dead vegetation, in soil, air and
Nadine Schmidt et al.
Biochemical pharmacology, 79(5), 722-732 (2009-10-27)
Chondrocytes are important for the development and maintenance of articular cartilage. However, both in osteoarthritis (OA) and rheumatoid arthritis (RA) chondrocytes are involved in the process of cartilage degradation and synthesize important immunomodulatory mediators, including nitric oxide (NO) generated by
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML0772-5MG | 04061832724065 |
| SML0772-1MG | 04061826293652 |