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Merck
CN

SML0786

Sigma-Aldrich

Decursin

From Radix peucedani, ≥97% (HPLC), anticancer agent, powder

别名:

(+)-Decursin, (7S)-7,8-Dihydro-8,8-dimethyl-2-oxo-2H,6H-benzo[1,2-b:5,4-b′]dipyran-7-yl 3-methyl-2-butenoate, 3-Methyl-2-butenoic acid (7S)-7,8-dihydro-8,8-dimethyl-2-oxo-2H,6H-pyrano[3,2-g]-1-benzopyran-7-yl ester

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关于此项目

经验公式（希尔记法）:
C19H20O5
化学文摘社编号:
5928-25-6
分子量:
328.36
MDL编号:
MFCD00272154
UNSPSC代码:
12352200
NACRES:
NA.77

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产品名称

Decursin, ≥97% (HPLC)

生物来源

Radix peucedani

质量水平

100

方案

≥97% (HPLC)

表单

powder

旋光性

[α]/D +120 to +160°, c = 0.5 in chloroform-d

颜色

white to beige

溶解性

DMSO: 5 mg/mL, clear

运输

wet ice

储存温度

−20°C

SMILES字符串

[o]1c2c(cc3c(c2)OC([C@H](C3)OC(=O)C=C(C)C)(C)C)cc[c]1=O

InChI

1S/C19H20O5/c1-11(2)7-18(21)23-16-9-13-8-12-5-6-17(20)22-14(12)10-15(13)24-19(16,3)4/h5-8,10,16H,9H2,1-4H3/t16-/m0/s1

InChI key

CUKSFECWKQBVED-INIZCTEOSA-N

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相关类别

生化/生理作用

Decursin is a cumarin isolated from Radix peucedani that exhibits a number of physiological actions including anticancer, antibacterial, antinematodal and antioxidant.
Decursin is a cumarin isolated from Radix peucedani that exhibits a number of physiological actions including anticancer, antibacterial, antinematodal and antioxidant. Decursin is potent anti-angiogenic agent targeting the VEGFR-2 signaling pathway. Decursin exhibits potent neuroprotective activity against glutamate and Ab- induced neurotoxicity. Apparently, decursin stimulates activation of Nerf2. Also, decursin inhibits androgen stimulated AR translocation to the nucleus in LNCaP prostate cancer cells.

特点和优势

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000426820
0000426820
0000279566
0000215000
0000214999

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Hyun Jung Kim et al.
Cancer letters, 301(1), 29-37 (2010-12-03)
Recent reports have indicated that decursin can induce apoptosis, suppress tumor growth, and inhibit angiogenesis. In this experiment, we investigated how decursin could potentiate the cytotoxic effects of bortezomib in human multiple myeloma cells. We found that decursin inhibited cell
Hyun Seo Park et al.
Planta medica, 78(9), 909-913 (2012-05-11)
Decursin is considered the major bioactive compound of Angelica gigas roots, a popular Oriental herb and dietary supplement. In this study, the pharmacokinetics of decursin and its active metabolite, decursinol, were evaluated after the administration of decursin in rats. The
Seung-Hee Lee et al.
Cell biology international, 36(7), 683-688 (2012-06-12)
Decursin and related coumarin compounds in herbal extracts have a number of biological activities against inflammation, angiogenesis and cancer. We have analysed a derivative of decursin (CSL-32) for activity against inflammatory activation of cancer cells, such as migration, invasion and
Kyeong-Ok Choi et al.
Journal of medicinal food, 15(10), 863-872 (2012-10-09)
The root of Angelica gigas (Korean angelica) is traditionally used to treat women's ailments that are caused by an impairment of menstrual blood flow and cycle irregularities. This study evaluated the effect particle size of Korean angelica powder on its
In Sik Kim et al.
Molecular biology reports, 40(3), 2541-2548 (2013-01-08)
(S)-(+)-decursin is a biological coumarin compound isolated from Angelica gigas Nakai. (S)-(+)-decursin and its analogue have a variety of pharmacological activities. In the present study, the anti-inflammatory effect of a (S)-(+)-decursin derivative, (S)-(+)-3-(3,4-dihydroxy-phenyl)-acrylic acid 2,2-dimethyl-8-oxo-3,4-dihydro-2H,8H-pyrano [3,2-g]-chromen-3-yl-ester (Compound 6, C6), on
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