SML0794
T2AA hydrochloride
≥98% (HPLC)
别名:
(S)-4-(4-(2-amino-3-hydroxypropyl)-2,6-diiodophenoxy)phenol hydrochloride, T2-aminoalcohol hydrochloride
SMILES string
Ic1c(c(cc(c1)C[C@H](N)CO)I)Oc2ccc(cc2)O
InChI
1S/C15H15I2NO3/c16-13-6-9(5-10(18)8-19)7-14(17)15(13)21-12-3-1-11(20)2-4-12/h1-4,6-7,10,19-20H,5,8,18H2/t10-/m0/s1
InChI key
NKOSKXJRVWVXRI-JTQLQIEISA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
Quality Level
Application
T2AA hydrochloride has been used as a chemical inhibitor of proliferating cell nuclear antigen (PCNA) in vaccinia virus.
Biochem/physiol Actions
T2AA is an inhibitor of PCNA/ PIP-Box interactions that binds to the PCNA cavity that interacts with PIP-Box sequences. Also T2AA inhibits PCNA Polδ3 interaction. T2AA inhibits de novo DNA synthesis, and in combination of cisplatin significantly increases growth inhibition in cancer cells. T2AA is a T3 analog that exhibits almost no thyroid hormone activity.
T2AA is an inhibitor of PCNA/ PIP-Box interactions; inhibits PCNA Polδ3 interaction.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Cytoplasmic ATR activation promotes vaccinia virus genome replication.
Postigo A, et al.
Cell Reports, 19(5), 1022-1032 (2017)
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