SML0805
CID16020046
≥98% (HPLC)
别名:
4-[4,6-Dihydro-4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxopyrrolo[3,4-c]pyrazol-5(1H)-yl]-benzoic acid
SMILES string
[nH]1nc(c3c1C(=O)N(C3c5cc(ccc5)O)c4ccc(cc4)C(=O)O)c2ccc(cc2)C
InChI
1S/C25H19N3O4/c1-14-5-7-15(8-6-14)21-20-22(27-26-21)24(30)28(18-11-9-16(10-12-18)25(31)32)23(20)17-3-2-4-19(29)13-17/h2-13,23,29H,1H3,(H,26,27)(H,31,32)
InChI key
VGUQVYZXABOXCX-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 1 mg/mL, clear (warmed)
storage temp.
2-8°C
Quality Level
Application
CID16020046 has been used as an antagonist of G-protein coupled receptor (GPR55) to test its effect on nociceptive behavior in rats induced with formalin.
Biochem/physiol Actions
CID16020046 is a potent and a selective GPR55 antagonist that inhibits GPR55-mediated ERK1/2 phosphorylation. CID16020046 inhibits LPI-induced Ca2+ signaling in HEK-GPR55 cells.
CID16020046 is a potent and a selective GPR55 antagonist.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Bright N Okine et al.
Neuroscience, 443, 19-29 (2020-07-17)
The G-protein coupled receptor, GPR55, modulates nociceptive processing. Given the expression of GPR55 in the anterior cingulate cortex (ACC), a key brain region involved in the cognitive and affective dimensions of pain, the present study tested the hypothesis that GPR55
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