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Merck
CN

SML0807

Sigma-Aldrich

PreQ1 dihydrochloride

≥98% (HPLC), PreQ1 riboswitch regulator, powder

别名:

2-Amino-5-(aminomethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one dihydrochloride, 7-Aminomethyl-7-deazaguanine dihydrochloride, Pre-queuosine1 dihydrochloride

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关于此项目

经验公式（希尔记法）:
C7H9N5O · 2HCl
化学文摘社编号:
86694-45-3
分子量:
252.10
UNSPSC代码:
12352200
NACRES:
NA.77

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产品名称

PreQ1 dihydrochloride, ≥98% (HPLC)

质量水平

100

方案

≥98% (HPLC)

表单

powder

储存条件

desiccated

颜色

white to light brown

溶解性

DMSO: 5 mg/mL, clear (warmed)

储存温度

2-8°C

SMILES字符串

Cl.Cl.[nH]1c2nc([nH][c](c2c(c1)CN)=O)N

InChI key

WUMBRQKOLVTYTB-UHFFFAOYSA-N

相关类别

生化/生理作用

PreQ1 (pre-queuosine1) is an intermediate of the queuosine pathway. Also, PreQ1 binds with high affinity to the aptamer of PreQ1 riboswitch, which attenuates protein expression.
PreQ1 (pre-queuosine1), an intermediate of the queuosine pathway, regulates the PreQ1 riboswitch.
PreQ1 is a nucleobase derived from guanine and a precursor of the modified base queuosine that is present in four tRNAs. Prequeuosine (preQ1) riboswitches are RNA regulatory elements present in the 5′ UTR of genes that participates in the biosynthesis and transport of preQ1.

特点和优势

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000296339
0000296339
0000237260
0000237260
0000205603

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Structural determinants for ligand capture by a class II preQ1 riboswitch
Kang M, et al.
Proceedings of the National Academy of Sciences of the USA, 111(6), E663-E671 (2014)
Zhou Gong et al.
Journal of molecular biology, 432(16), 4523-4543 (2020-06-12)
Single-stranded noncoding regulatory RNAs, as exemplified by bacterial riboswitches, are highly dynamic. The conformational dynamics allow the riboswitch to reach maximum switching efficiency under appropriate conditions. Here we characterize the conformational dynamics of preQ1 riboswitches from mesophilic and thermophilic bacterial
Yifeng Yuan et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(38), 19126-19135 (2019-09-05)
Queuosine (Q) is a complex tRNA modification widespread in eukaryotes and bacteria that contributes to the efficiency and accuracy of protein synthesis. Eukaryotes are not capable of Q synthesis and rely on salvage of the queuine base (q) as a
Structural, Functional, and Taxonomic Diversity of Three PreQ1 Riboswitch Classes
McCown PJ, et al.
Chemistry & Biology, 21(7), 880-889 (2014)

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