Merck
CN

SML0832

Sigma-Aldrich

TLR4-IN-C34

≥98% (HPLC)

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别名:
2-乙酰氨基吡喃糖苷, C34, 异丙基 2-(乙酰氨基)-2-脱氧 α-D-吡喃葡萄糖苷 3,4,6-三乙酸酯
Empirical Formula (Hill Notation):
C17H27NO9
CAS号:
分子量:
389.40
NACRES:
NA.77

质量水平

检测方案

≥98% (HPLC)

形式

powder

储存条件

desiccated

颜色

white to beige

溶解性

H2O: 1 mg/mL, clear (warmed)

储存温度

−20°C

InChI

1S/C17H27NO9/c1-8(2)24-17-14(18-9(3)19)16(26-12(6)22)15(25-11(5)21)13(27-17)7-23-10(4)20/h8,13-17H,7H2,1-6H3,(H,18,19)/t13-,14-,15-,16-,17+/m1/s1

InChI key

KMIQMFHPUJUDMC-HHARLNAUSA-N

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614316614310SAB1404475
Sigma-Aldrich

Sigma-Aldrich

SML0832

TLR4-IN-C34

TLR4 Inhibitor, TAK-242 TAK-242; CAS 243984-11-4; is a cell-permeable compound that selectively binds to Cys747 of TLR4 and selectively disrupts its interaction with adaptor molecules TIRAP and TRAM.

Sigma-Aldrich

614316

TLR4抑制剂,TAK-242

form

powder

form

solid

form

solid

form

buffered aqueous solution

storage condition

desiccated

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

-

color

white to beige

color

white to yellow-white

color

white

color

-

solubility

H2O: 1 mg/mL, clear (warmed)

solubility

DMSO: 100 mg/mL

solubility

DMSO: 50 mg/mL

solubility

-

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

一般描述

TLR4-IN-C34 是体外体内 toll 样受体 4(TLR4)的抑制剂。

应用

TLR4-IN-C34 已作为一种抑制剂用在喂食高脂饮食的小鼠中,以在体内验证上述体外途径(硬脂酸/LDH-α/细胞因子)。

生化/生理作用

TLR4-IN-C34 是 toll 样受体 4(TLR4)的有效和特异性抑制剂,其在体内体外抑制 TLR4 信号转导。TLR4-IN-C34,也称为 C34,是一种氨基单糖,通过与 TLR4 的共同受体-髓样分化蛋白-2 (MD-2)的疏水口袋对接来抑制 TLR4 信号。研究表明,C34 可降低实验性坏死性小肠结肠炎(NEC)的严重程度。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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1 of 2

Elikanah Olusayo Adegoke et al.
Journal of applied toxicology : JAT, 39(6), 832-843 (2019-01-24)
This study investigated the pharmacological inhibition of the toll-like receptor 4 (TLR4) genes as a measure to attenuate microcystin-LR (MC-LR) reproductive toxicity. Bovine Sertoli cells were pretreated with TLR4-IN-C34 (C34) for 1 hour. Thereafter the pretreated and non-pretreated Sertoli cells were
Stearic acid induces proinflammatory cytokine production partly through activation of lactate-HIF1α pathway in chondrocytes.
Miao H, et al.
Scientific Reports, 5, 13092-13092 (2015)
Elikanah Olusayo Adegoke et al.
Journal of applied toxicology : JAT, 39(6), 832-843 (2019-01-24)
This study investigated the pharmacological inhibition of the toll-like receptor 4 (TLR4) genes as a measure to attenuate microcystin-LR (MC-LR) reproductive toxicity. Bovine Sertoli cells were pretreated with TLR4-IN-C34 (C34) for 1 hour. Thereafter the pretreated and non-pretreated Sertoli cells were
Peter Wipf et al.
Tetrahedron letters, 56(23), 3097-3100 (2015-08-04)
The low-molecular weight isopropyl 2-acetamido-α-glucoside 16 (C34) inhibits toll-like receptor 4 (TLR4) in enterocytes and macrophages in vitro, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis. We used a copper(II)-mediated solvolysis of anomeric oxazolines and an
Xiaojuan Liu et al.
Journal of neuroinflammation, 16(1), 209-209 (2019-11-12)
Paclitaxel is a widely used and potent chemotherapeutic agent for the treatment of cancer. However, patients receiving paclitaxel often develop an acute pain syndrome for which there are few treatment options. Astrocytes play an important role in the pathogenesis of

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