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Merck
CN

SML0834

2,3,5,4′-四羟基二苯乙烯 2-O-β-D-葡萄糖苷

≥98% (HPLC)

别名:

2,4-二羟基-6-[(1E)-2-（4-羟基苯基）乙烯基] 苯基 β-D-吡喃葡萄糖苷, EH-201, THSG, 四羟基二苯乙烯苷

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关于此项目

经验公式（希尔记法）:
C20H22O9
化学文摘社编号:
82373-94-2
分子量:
406.38
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00238694

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产品名称

2,3,5,4′-四羟基二苯乙烯 2-O-β-D-葡萄糖苷, ≥98% (HPLC)

SMILES string

O1[C@H]([C@@H]([C@H]([C@@H]([C@H]1CO)O)O)O)Oc2c(cc(cc2\C=C\c3ccc(cc3)O)O)O

InChI

1S/C20H22O9/c21-9-15-16(25)17(26)18(27)20(28-15)29-19-11(7-13(23)8-14(19)24)4-1-10-2-5-12(22)6-3-10/h1-8,15-18,20-27H,9H2/b4-1+/t15-,16-,17+,18-,20+/m1/s1

InChI key

JAYVHSBYKLLDJC-DSNJPTTOSA-N

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to brown

solubility

H2O: 5 mg/mL, clear (warmed)

storage temp.

−20°C

Quality Level

100

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相关类别

Biochem/physiol Actions

2,3,5,4′-四羟基二苯乙烯 2-O-β-D-葡萄糖苷诱导表达，增强 EPO 的活性。
2,3,5,4′-四羟基二苯乙烯 2-O-β-D-葡萄糖苷诱导表达，增强 EPO 的活性。该化合物刺激非造血细胞中的线粒体生物合成和血红蛋白的表达。2,3,5,4'-四羟基二苯乙烯 2-O-β-D-葡萄糖苷在心血管疾病和缺血模型中表现出保护作用。
2,3,5,4′-四羟基芪 2-O-β-D-葡萄糖苷 (THSG) 具有抗炎、抗氧化和抗动脉粥样硬化的功能。它还对由1-甲基-4-苯基吡啶（MPP +）以及MPTP（1-甲基-4-苯基-1,2,3,6-四氢吡啶）诱发的帕金森′病所诱导的神经母细胞瘤细胞的细胞毒性有保护作用。通过其抗氧化功能，它可以阻止阿尔茨海默′病模型中的脂质过氧化。在结扎诱导的牙周炎中，THSG可抑制炎症。

Features and Benefits

这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

General description

2,3,5,4′ -四羟基芪-2-O-β-葡萄糖苷 (THSG) 是一种何首乌 （Polygoni Multiflori）多酚。

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000416713
0000416713
0000112901
0000032806
0000032807

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Hong He et al.
European journal of pharmacology, 767, 175-182 (2015-10-20)
Parkinson's disease (PD) is characterized by the selective death of dopaminergic neurons in the substantia nigra pars compacta. Oxidative stress-induced neuron loss is thought to play a crucial role in the pathogenesis of PD. Previous work from our group suggests
Yu-Tang Chin et al.
Mediators of inflammation, 2016, 6953459-6953459 (2016-08-10)
Periodontitis, a chronic infection by periodontopathic bacteria, induces uncontrolled inflammation, which leads to periodontal tissue destruction. 2,3,5,4'-Tetrahydroxystilbene-2-O-beta-glucoside (THSG), a polyphenol extracted from Polygoni Multiflori, reportedly has anti-inflammatory properties. In this study, we investigated the mechanisms of THSG on the Porphyromonas
Yun-Ho Hwang et al.
International journal of molecular sciences, 19(12) (2018-12-14)
Asthma is an inflammatory disease caused by an imbalance of Th1 and Th2 cells. In general, asthma is characterized by a stronger Th2 response. Most conventional asthma treatment focuses on improving airway flow or suppression of airway inflammation. To reduce

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