SML0835
PF74
≥98% (HPLC)
别名:
2-Methyl-N-[(1S)-2-(methylphenylamino)-2-oxo-1-(phenylmethyl)ethyl]- 1H-indole-3-acetamide, PF 3450074, PF-3450074
产品名称
PF74, ≥98% (HPLC)
SMILES string
[nH]1c2c(c(c1C)CC(=O)N[C@@H](Cc4ccccc4)C(=O)N(C)c3ccccc3)cccc2
InChI
1S/C27H27N3O2/c1-19-23(22-15-9-10-16-24(22)28-19)18-26(31)29-25(17-20-11-5-3-6-12-20)27(32)30(2)21-13-7-4-8-14-21/h3-16,25,28H,17-18H2,1-2H3,(H,29,31)/t25-/m0/s1
InChI key
ACDFWSNAQWFRRF-VWLOTQADSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
PF74 (PF-3450074) is a HIV-1 inhibitor that targets HIV capsid protein.
PF74 (PF-3450074) is a HIV-1 inhibitor that targets HIV capsid protein. PF74 binds specifically to HIV-1 particles and triggers premature HIV-1 uncoating in target cells.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Alžběta Dostálková et al.
Molecules (Basel, Switzerland), 25(8) (2020-04-25)
A major structural retroviral protein, capsid protein (CA), is able to oligomerize into two different hexameric lattices, which makes this protein a key component for both the early and late stages of HIV-1 replication. During the late stage, the CA
Doortje Borrenberghs et al.
Scientific reports, 6, 36485-36485 (2016-11-11)
Nuclear entry is a selective, dynamic process granting the HIV-1 pre-integration complex (PIC) access to the chromatin. Classical analysis of nuclear entry of heterogeneous viral particles only yields averaged information. We now have employed single-virus fluorescence methods to follow the
Muthukumar Balasubramaniam et al.
Journal of virology, 93(6) (2018-12-21)
The HIV-1 capsid protein (CA) facilitates reverse transcription and nuclear entry of the virus. However, CA's role in post-nuclear entry steps remains speculative. We describe a direct link between CA and integration by employing the capsid inhibitor PF74 as a
Doortje Borrenberghs et al.
Scientific reports, 6, 36485-36485 (2016-11-11)
Nuclear entry is a selective, dynamic process granting the HIV-1 pre-integration complex (PIC) access to the chromatin. Classical analysis of nuclear entry of heterogeneous viral particles only yields averaged information. We now have employed single-virus fluorescence methods to follow the
Ashwanth C Francis et al.
Cell host & microbe, 23(4), 536-548 (2018-04-13)
The HIV-1 core consists of capsid proteins (CA) surrounding viral genomic RNA. After virus-cell fusion, the core enters the cytoplasm and the capsid shell is lost through uncoating. CA loss precedes nuclear import and HIV integration into the host genome
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