SML0835
PF74
≥98% (HPLC)
别名:
2-Methyl-N-[(1S)-2-(methylphenylamino)-2-oxo-1-(phenylmethyl)ethyl]- 1H-indole-3-acetamide, PF 3450074, PF-3450074
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 5 mg/mL, clear (warmed)
储存温度
2-8°C
SMILES字符串
[nH]1c2c(c(c1C)CC(=O)N[C@@H](Cc4ccccc4)C(=O)N(C)c3ccccc3)cccc2
InChI
1S/C27H27N3O2/c1-19-23(22-15-9-10-16-24(22)28-19)18-26(31)29-25(17-20-11-5-3-6-12-20)27(32)30(2)21-13-7-4-8-14-21/h3-16,25,28H,17-18H2,1-2H3,(H,29,31)/t25-/m0/s1
InChI key
ACDFWSNAQWFRRF-VWLOTQADSA-N
相关类别
生化/生理作用
PF74 (PF-3450074) is a HIV-1 inhibitor that targets HIV capsid protein.
PF74 (PF-3450074) is a HIV-1 inhibitor that targets HIV capsid protein. PF74 binds specifically to HIV-1 particles and triggers premature HIV-1 uncoating in target cells.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
D S Heller et al.
International journal of fertility, 37(5), 283-285 (1992-09-01)
Patients with complete androgen insensitivity syndrome rarely have Müllerian remnants. A patient with this syndrome found to have a microscopic fallopian tube at the time of gonadectomy is described and possible etiologies for the finding are discussed.
Doortje Borrenberghs et al.
Scientific reports, 6, 36485-36485 (2016-11-11)
Nuclear entry is a selective, dynamic process granting the HIV-1 pre-integration complex (PIC) access to the chromatin. Classical analysis of nuclear entry of heterogeneous viral particles only yields averaged information. We now have employed single-virus fluorescence methods to follow the
Ashwanth C Francis et al.
Cell host & microbe, 23(4), 536-548 (2018-04-13)
The HIV-1 core consists of capsid proteins (CA) surrounding viral genomic RNA. After virus-cell fusion, the core enters the cytoplasm and the capsid shell is lost through uncoating. CA loss precedes nuclear import and HIV integration into the host genome
Alžběta Dostálková et al.
Molecules (Basel, Switzerland), 25(8) (2020-04-25)
A major structural retroviral protein, capsid protein (CA), is able to oligomerize into two different hexameric lattices, which makes this protein a key component for both the early and late stages of HIV-1 replication. During the late stage, the CA
Doortje Borrenberghs et al.
Scientific reports, 6, 36485-36485 (2016-11-11)
Nuclear entry is a selective, dynamic process granting the HIV-1 pre-integration complex (PIC) access to the chromatin. Classical analysis of nuclear entry of heterogeneous viral particles only yields averaged information. We now have employed single-virus fluorescence methods to follow the
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