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SML0843

ISRIB

Name: ISRIB
Brand: SIGMA

≥98% (HPLC), powder, integrated stress response inhibitor

别名:

反式-N,N′-1,4-环己烷二基双 \ [2-（4-氯苯氧基）-乙酰胺, 反式-N,N′-（环己烷-1,4-二基）双（2-（4-氯苯氧基）乙酰胺, 整合应激反应抑制剂

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关于此项目

经验公式（希尔记法）:

C₂₂H₂₄Cl₂N₂O₄

化学文摘社编号:

1597403-47-8

分子量:

451.34

UNSPSC Code:

12352200

PubChem Substance ID:

329825607

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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产品名称

ISRIB, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 1 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

ClC1=CC=C(OCC(N[C@@H]2CC[C@@H](NC(COC3=CC=C(Cl)C=C3)=O)CC2)=O)C=C1

InChI

1S/C22H24Cl2N2O4/c23-15-1-9-19(10-2-15)29-13-21(27)25-17-5-7-18(8-6-17)26-22(28)14-30-20-11-3-16(24)4-12-20/h1-4,9-12,17-18H,5-8,13-14H2,(H,25,27)(H,26,28)/t17-,18-

InChI key

HJGMCDHQPXTGAV-IYARVYRRSA-N

Application

ISRIB（综合应激反应抑制剂）已被用作综合应激反应的抑制剂。

Biochem/physiol Actions

ISRIB（综合应激反应抑制剂）作为一种药物，赋予细胞抵抗真核起始因子2（eIF2）α磷酸化（如激活转录因子4（ATF4）和真核翻译起始因子4E（eIF4E）结合）的下游作用的抗性蛋白质1（4E-BP1）诱导。

ISRIB 是一种血脑屏障渗透剂，是内质网应激适应性受损的有效选择性综合应激反应 (ISR) 抑制剂。ISRIB 是 PERK 信号的有效抑制剂，可有效逆转 eIF2a 磷酸化作用，恢复细胞翻译能力。ISRIB 增强啮齿类动物的认知记忆。

ISRIB 是一种血脑屏障渗透剂，是强效选择性 PERK 信号通路抑制剂；认知记忆增强剂。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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全球贸易项目编号

货号	GTIN
SML0843-25MG	04061832451046
SML0843-5MG	04061832451053

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