SML0853
SB 699551 dihydrochloride
≥98% (HPLC)
别名:
N-[2-(Dimethylamino)ethyl]-N-[[4′-[[(2-phenylethyl)amino]methyl][1,1′-biphenyl]-4-yl]methyl]-cyclopentanepropanamide dihydrochloride
产品名称
SB 699551 dihydrochloride, ≥98% (HPLC)
SMILES string
Cl.Cl.N(CCN(Cc2ccc(cc2)c3ccc(cc3)CNCCc4ccccc4)C(=O)CCC1CCCC1)(C)C
InChI
1S/C34H45N3O.2ClH/c1-36(2)24-25-37(34(38)21-16-28-10-6-7-11-28)27-31-14-19-33(20-15-31)32-17-12-30(13-18-32)26-35-23-22-29-8-4-3-5-9-29;;/h3-5,8-9,12-15,17-20,28,35H,6-7,10-11,16,21-27H2,1-2H3;2*1H
InChI key
QJMKBIHLMPTYTI-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
H2O: 1 mg/mL, clear (warmed)
storage temp.
2-8°C
Quality Level
Application
SB 699551 dihydrochloride has been used to identify the antagonism of 5-HT2AR in cell culture-derived hepatitis C virus (HCVcc).
Biochem/physiol Actions
SB 699551 dihydrochloride is also known as (3-cyclopentyl-N-[2-(dimethylamino)ethyl]-N-[(4′-{[(2-phenylethyl)amino]methyl}-4-biphenylyl)methyl]propanamide dihydrochloride). It is considered as a useful tool to explain the physiological roles of the 5-ht5A receptor.
SB-699551 is 5-HT5A receptor antagonist.
SB-699551 is a 5-HT5A receptor antagonist, (pKi = 8.3) with 100-fold selectivity over other 5-HT receptor populations. SB-699551 completely blocks 5-HT-induced [35S]GTPγS membrane binding in cells expressing recombinant guinea pig 5-HT-5A.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Identification of serotonin 2A receptor as a novel HCV entry factor by a chemical biology strategy
Cao, et al.
Protein & cell, 1-18 (2018)
5-ht5A receptors as a therapeutic target
Thomas, David R
Pharmacology & Therapeutics, 111(3), 707-714 (2006)
Lin Cao et al.
Protein & cell, 10(3), 178-195 (2018-03-16)
Hepatitis C virus (HCV) is a leading cause of liver disease worldwide. Although several HCV protease/polymerase inhibitors were recently approved by U.S. FDA, the combination of antivirals targeting multiple processes of HCV lifecycle would optimize anti-HCV therapy and against potential
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