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Merck
CN

SML0860

Sigma-Aldrich

阿比朵尔 盐酸盐

≥98% (HPLC)

别名:

6-溴-4-((二甲氨基)甲基)-5-羟基-1-甲基-2-((苯硫基)甲基)-1H-吲哚-3-羧酸乙酯 单盐酸盐

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关于此项目

经验公式(希尔记法):
C22H25BrN2O3S · HCl
化学文摘社编号:
分子量:
513.88
UNSPSC代码:
12352200
NACRES:
NA.77
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方案

≥98% (HPLC)

表单

powder

储存条件

desiccated

颜色

white to beige

溶解性

DMSO: 20 mg/mL, clear

储存温度

−20°C

SMILES字符串

S(Cc2[n](c3c(c(c(c(c3)Br)O)CN(C)C)c2C(=O)OCC)C)c1ccccc1.[Cl-].O.[H+]

InChI

1S/C22H25BrN2O3S.ClH.H2O/c1-5-28-22(27)20-18(13-29-14-9-7-6-8-10-14)25(4)17-11-16(23)21(26)15(19(17)20)12-24(2)3;;/h6-11,26H,5,12-13H2,1-4H3;1H;1H2

InChI key

PLWQHPWNKPKQJT-UHFFFAOYSA-N

生化/生理作用

盐酸阿比多尔(ARB)是一种小分子单眼用化合物。用于预防流感病毒(IFV)诱导的重症肺炎和病毒相关细胞因子失调。ARB还具有一些免疫调节特性,包括干扰素诱导和巨噬细胞活化的作用。
阿比多尔是一种广谱抗病毒药,已证明对多种包膜和非包膜病毒具有活性,并在临床上用于治疗流感。阿比多尔抑制病毒进入宿主细胞并刺激免疫反应。阿比多尔抑制病毒衣壳与靶细胞的细胞膜之间的融合,从而防止病毒进入。
阿比多尔是一种抗流感抗病毒药。

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

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Qiang Zhang et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 45(3), 289-299 (2011-03-01)
Influenza is a major threat to millions of people worldwide. Vaccines and antiviral agents are two main options available to reduce the impact of the influenza virus, while anti-influenza agents are the most effective means to prevent the transmission of
Xin Xiong et al.
Journal of AOAC International, 94(4), 1100-1105 (2011-09-17)
An HPLC/MS/MS method for the determination of arbidol in human plasma was developed. Arbidol and internal standard (loratadine) were extracted from alkaline plasma with tert-butyl methyl ether and analyzed on a Zorbax SB C18 column (30 x 2.1 mm id
S Ia Loginova et al.
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 55(1-2), 6-11 (2010-06-30)
Efficacy of arbidol and ridostin in cupping postvaccinal complications due to variolation was studied by the clinico-virological, hematological and biochemical indices and it was shown that arbidol was efficient in cupping development of dermal complications, lowered the severity of the
A A Romanovskaia et al.
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 54(5-6), 41-47 (2010-01-08)
Biological properties of influenza viruses A (H1N1), that were the cause of the infection in humans in April - May 2009, and the action of the Russian antivirals on their reproduction were studied in vitro. The nucleotide sequence in the
Ilenia Delogu et al.
Antiviral research, 90(3), 99-107 (2011-03-29)
Arbidol (ARB) is an antiviral drug originally licensed in Russia for use against influenza and other respiratory viral infections. Although a broad-spectrum antiviral activity has been reported for this drug, there is until now no data regarding its effects against

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