SML0864
EMPA
≥98% (HPLC)
别名:
N-Ethyl-2-[(6-methoxy-3-pyridinyl)[(2-methylphenyl)sulfonyl]amino]-N-(3-pyridinylmethyl)-acetamide
SMILES string
[S](=O)(=O)(N(CC(=O)N(CC)Cc3cnccc3)c2cnc(cc2)OC)c1c(cccc1)C
InChI
1S/C23H26N4O4S/c1-4-26(16-19-9-7-13-24-14-19)23(28)17-27(20-11-12-22(31-3)25-15-20)32(29,30)21-10-6-5-8-18(21)2/h5-15H,4,16-17H2,1-3H3
InChI key
KJPHTXTWFHVJIG-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
film
color
white to light brown
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
EMPA is a potent, selective OX2R antagonist (IC50 = 2.3 nM). EMPA binds reversibly to OX2R and inhibits orexin-a and -b-evoked intracellular calcium flux in cells expressing recombinant OX2R, but not OX1R.
EMPA is a potent, selective OX2R antagonist.
Physical form
This product is solubilized for packaging and then dried down for shipment. It would appear as a lyophilized powder or film on the vial. Solvent should be added directly to the vial to prepare their sample for testing.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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