SML0873
Y16
≥98% (HPLC)
别名:
4-[[3-[(3-Methylphenyl)methoxy]phenyl]methylene]-1-phenyl-3,5-pyrazolidinedione
产品名称
Y16, ≥98% (HPLC)
SMILES string
N2(NC(=O)C(=Cc3cc(ccc3)OCc4cc(ccc4)C)C2=O)c1ccccc1
InChI key
ITMLWGWTDWJSRZ-UHFFFAOYSA-N
InChI
1S/C24H20N2O3/c1-17-7-5-9-19(13-17)16-29-21-12-6-8-18(14-21)15-22-23(27)25-26(24(22)28)20-10-3-2-4-11-20/h2-15H,16H2,1H3,(H,25,27)
assay
≥98% (HPLC)
form
powder
color
, faint yellow to dark orange
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Y16 blocks the binding of LARG, a DBL-family Rho guanine nucleotide exchange factor, with Rho (Kd = 80 nM). Y16 specifically inhibits LARG catalyzed activation of RhoA and RhoA signaling pathways. Y16 blocks the growth and migration of MCF7 breast cancer cells.
Y16 blocks the binding of LARG, a DBL-family Rho guanine nucleotide exchange factor.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GTP Binding Proteins (Low Molecular Weight) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Other Notes
Product is a racemic mixture of E/Z isomers.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Bo Zhang et al.
Cells, 9(3) (2020-03-08)
Rho GTPases, including Rho, Cdc42, Rac and ROP subfamilies, are key signaling molecules in RNA polymerase II (Pol II) transcriptional control. Our prior work has shown that plant ROP and yeast Cdc42 GTPases similarly modulate Ser2 and Ser5 phosphorylation status
Sreeharsha Gurrapu et al.
Cell death and differentiation, 25(7), 1259-1275 (2018-03-21)
Semaphorin 4C (Sema4C) expression in human breast cancers correlates with poor disease outcome. Surprisingly, upon knock-down of Sema4C or its receptor PlexinB2 in diverse mammary carcinoma cells (but not their normal counterparts), we observed dramatic growth inhibition associated with impairment
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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