SML0874
GMQ hydrochloride
≥95% (HPLC)
别名:
2-Guanidine-4-methylquinazoline hydrochloride, 4-Methyl-2-guanidino quinazoline hydrochloride, N-(4-Methyl-2-quinazolinyl)-guanidine hydrochloride, NSC 403387 hydrochloride
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关于此项目
经验公式（希尔记法）:
C10H11N5 · HCl
化学文摘社编号:
分子量:
237.69
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
GMQ hydrochloride, ≥95% (HPLC)
InChI
1S/C10H11N5.ClH/c1-6-7-4-2-3-5-8(7)14-10(13-6)15-9(11)12;/h2-5H,1H3,(H4,11,12,13,14,15);1H
SMILES string
CC1=NC(NC(N)=N)=NC2=C1C=CC=C2.Cl
InChI key
VNPZWQRWOHFAPD-UHFFFAOYSA-N
assay
≥95% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
room temp
Quality Level
Biochem/physiol Actions
GMQ/2-Guanidine-4-methylquinazoline is a potent and selective modulator of acid-sensing ion channel (ASIC) that activates ASIC3 channels under neutral pH. GQM blocks acid-induced maximal peak current and alters ASICs pH dependence for activation and inactivation.
GMQ/2-guanidine-4-methylquinazoline is a potent and selective modulator of acid-sensing ion channel (ASIC).
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Kojun Tsuji et al.
American journal of physiology. Gastrointestinal and liver physiology, 319(5), G564-G572 (2020-09-04)
Capsaicin powerfully evokes the swallowing reflex and is a known therapeutic agent for improving dysphagia and preventing aspiration pneumonia. However, the role of capsaicin-sensitive nerves in the initiation of swallowing evoked by various natural stimuli remains unclear. To explore this
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