SML0884
bpV(HOpic)
≥90% V basis
别名:
K2[VO(O2)2C6H4NO3], 双过氧酸二钾(5-羟基吡啶-2-羧基)氧钒酸盐(V), 双过氧钒(HOpic)
产品名称
bpV(HOpic), ≥90% V basis
SMILES string
[V]32(OO3)(OO2)([NH]1=CC(=O)CC=C1C(=O)[O-])[O-].[K+].[K+].O.O.O.O
InChI key
HSCJTESZNNRNPK-UHFFFAOYSA-M
InChI
1S/C6H5NO3.2K.2O2.4H2O.O.V/c8-4-1-2-5(6(9)10)7-3-4;;;2*1-2;;;;;;/h2-3H,1H2,(H,9,10);;;;;4*1H2;;/q;2*+1;2*-2;;;;;-1;+4/p-1
assay
≥90% V basis
form
powder
storage condition
desiccated
protect from light
color
faintly yellow to dark yellow
solubility
H2O: 20 mg/mL, clear
storage temp.
−20°C
Quality Level
相关类别
Application
bpV(HOpic)已被用于细胞迁移相关信号通路的药理学干扰。
Biochem/physiol Actions
bpV(OHpic)是蛋白质磷酸酪氨酸磷酸酶的一种双过氧化钒抑制剂，具有对PTEN的选择性。
bpV(OHpic)是蛋白质磷酸酪氨酸磷酸酶的一种双过氧化钒抑制剂，对PTEN、磷酸酶和张力蛋白同源物具有选择性，而后者是一种参与细胞周期调节的肿瘤抑制磷酸酶。bpV(HOpic)对PTEN的IC50值为14 nM，而PTPβ为4.9 μM、PTP-1β为25.3 μM。bpV(HOpic)已被证明可增强能够防止心肌缺血再灌注损伤的PI3K/Akt信号转导。
Other Notes
可溶于DMSO或水。注意：该产品在水中不稳定。在溶解后会立即发生分解。分解的速度低于在干燥的DMSO中。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Directed migration of cancer cells guided by the graded texture of the underlying matrix.
Park J, et al.
Nature Materials, 15(7), 792-792 (2016)
Thomas Theis et al.
Molecular neurobiology, 55(10), 8203-8215 (2018-03-10)
Glycosylation fine-tunes signal transduction of adhesion molecules during neural development and supports synaptic plasticity and repair after injury in the adult nervous system. One abundantly expressed neural glycan is LewisX (LeX). Although it is known that its expression starts at
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