SML0888
Sertaconazole nitrate
≥98% (HPLC)
别名:
1-[2-[(7-Chlorobenzo[b]thien-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole nitrate
SMILES string
[s]1c2c(c(c1)COC(C[n]4cncc4)c3c(cc(cc3)Cl)Cl)cccc2Cl.[N+](=O)([O-])O
InChI
1S/C20H15Cl3N2OS.HNO3/c21-14-4-5-16(18(23)8-14)19(9-25-7-6-24-12-25)26-10-13-11-27-20-15(13)2-1-3-17(20)22;2-1(3)4/h1-8,11-12,19H,9-10H2;(H,2,3,4)
InChI key
HAAITRDZHUANGT-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Sertaconazole nitrate is an antifungal agent with anti-inflammatory and anti-itch activity. Topical administration of this drug reduces the releases of cytokines from activated T-cell enriched human lymphocytes. Sertaconazole nitrate has been used as a highly safe and effective therapeutic for treating tinea pedis interdigitalis. It is also used to treat contact hypersensitivity and irritant contact dermatitis.
Sertaconazole nitrate is an imidazole antifungal.
Sertaconazole nitrate is an imidazole antifungal. Like other imidazole antifungals, sertaconazole blocks the synthesis of ergosterol, an essential component of the fungal cell membrane, by inhibiting the P450 enzyme 14α-demethylase that converts lanosterol to ergosterol.
Hazard Classifications
Repr. 2
signalword
Warning
hcodes
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Frank Liebel et al.
Archives of dermatological research, 298(4), 191-199 (2006-07-27)
Cutaneous fungal infections are frequently associated with an inflammatory component including irritated skin, itching and stinging/burning. Therapeutic anti-fungal agents that have anti-inflammatory activity have the potential to provide clinical benefit beyond fungus eradication. Recently, certain anti-fungal agents have been shown
Safety and efficacy of sertaconazole nitrate cream 2% in the treatment of tinea pedis interdigitalis: a subgroup analysis.
Borelli C, et al.
Cutis; Cutaneous Medicine for the Practitioner, 85(2), 107-111 (2010)
Anti-Inflammatory Activity of Sertaconazole Nitrate Is Mediated via Activation of a p38?COX-2?PGE2 Pathway.
Sur R, et al.
The Journal of Investigative Dermatology, 128(2), 336-344 (2008)
商品
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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