Name: ALX 5407 hydrochloride
Brand: SIGMA

登录查看公司和协议定价

About This Item

经验公式（希尔记法）:

C₂₄H₂₄NO₃F·HCl

CAS Number:

200006-08-2

分子量:

429.91

MDL编号:

MFCD09971056

UNSPSC代码:

12352200

PubChem化学物质编号:

329825613

NACRES:

NA.77

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

质量水平

100

方案

≥98% (HPLC)

表单

powder

储存条件

desiccated

颜色

white to beige

溶解性

DMSO: 5 mg/mL, clear (warmed)

储存温度

2-8°C

SMILES字符串

Cl.CN(CC[C@@H](Oc1ccc(cc1)-c2ccccc2)c3ccc(F)cc3)CC(O)=O

InChI

1S/C24H24FNO3.ClH/c1-26(17-24(27)28)16-15-23(20-7-11-21(25)12-8-20)29-22-13-9-19(10-14-22)18-5-3-2-4-6-18;/h2-14,23H,15-17H2,1H3,(H,27,28);1H/t23-;/m1./s1

InChI key

RPDGSZCYSJWQEE-GNAFDRTKSA-N

正在寻找类似产品? 访问产品对比指南

应用

ALX 5407 hydrochloride has been used as a glycine transporter (GlyT1) inhibitor to test its effect on inhibitory postsynaptic current and N-methyl-D-aspartate receptor (NMDA)-mediated excitatory postsynaptic currents (EPSCs). It has also been used as a GlyT1 inhibitor to treat developmentally diminished NMDA receptor (Grin1D481N) mice to test its effect on the glycine site function.

生化/生理作用

ALX 5407 is a selective, irreversible GlyT-1 glycine transporter inhibitor.

ALX-5407 hydrochloride (NFPS hydrochloride) is a selective irreversible inhibitor of the glycine transporter GlyT1 with IC₅₀ values of 3 nM for GlyT1 compared to 100 μM for GlyT2. ALX-5407 hydrochloride showed no activity at the inhibitory glycine receptor or glycine site of the NMDA receptor (IC₅₀ > 100 mM).

特点和优势

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.