SML0909
平痛新 盐酸盐
≥98% (HPLC), neurotransmitter reuptake inhibitor, powder
别名:
3,4,5,6-四氢-5-甲基-1-苯基-1H-2,5-氧氮苯并辛因 盐酸盐
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经验公式（希尔记法）:
C17H19NO · HCl
化学文摘社编号:
分子量:
289.80
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
245-585-5
MDL number:
产品名称
平痛新 盐酸盐, ≥98% (HPLC)
InChI key
CNNVSINJDJNHQK-UHFFFAOYSA-N
InChI
1S/C17H19NO.ClH/c1-18-11-12-19-17(14-7-3-2-4-8-14)16-10-6-5-9-15(16)13-18;/h2-10,17H,11-13H2,1H3;1H
SMILES string
Cl.CN1CCOC(c2ccccc2)c3ccccc3C1
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
mp
260 °C (dec.) (lit.)
solubility
H2O: 5 mg/mL, clear
storage temp.
2-8°C
Quality Level
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Application
Nefopam hydrochloride has been used as a standard for the quantitative determination of tramadol by gas chromatography–mass spectrometry (GC/MS).
Biochem/physiol Actions
Nefopam is a centrally-acting analgesic drug of the benzoxazocine chemical class. Nefopam is a non-opioid, but has a potentiating effect on morphine and other opioids. Its mechanism of action is not certain, but may involve its action as a dopamine/serotonin/norepinephrine reuptake inhibitor.
Nefopam is a centrally-acting non-opioid analgesic drug of the benzoxazocine chemical class.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Xiaodong Sun et al.
Chirality, 31(2), 118-126 (2019-01-05)
In this work, a new capillary electrokinetic chromatography (EKC) approach using ethanediamine-bonded poly (glycidyl methacrylate) (Ami-PGMA) microspheres as pseudostationary phases (PSPs) for enantioseparation with a polysaccharide, chondroitin sulfate E (CSE), as the chiral selector. The CSE@Ami-PGMA EKC system was applied
Deborah E Kerr et al.
Emergency medicine journal : EMJ, 27(5), 407-408 (2010-04-03)
Nefopam hydrochloride (Acupan) is a potent non-opioid analgesic widely used for the relief of moderate to severe postoperative pain. The drug is generally well tolerated, but it has a broad spectrum of side effects including tachycardia, sweating, nausea, seizures and
F Lamazou et al.
Gynecologie, obstetrique & fertilite, 38(4), 278-282 (2010-04-07)
We report the case of a 21-year-old pregnant women (36 WA) presenting intensive headaches and visual disturbances. Those sellar compression symptoms have made us suppose the diagnosis of autoimmune hypophysitis. MRI has confirmed the typical aspect of symmetric enlargement of
G Chanques et al.
British journal of anaesthesia, 106(3), 336-343 (2011-01-06)
Pain management is challenging in intensive care unit (ICU) patients. The analgesic efficacy, tolerance, and haemodynamic effects of nefopam have never been described in critically ill patients. In consecutive medical-surgical ICU patients who received 20 mg of nefopam i.v. over
Validation of a GC/MS method for the determination of tramadol in human plasma after intravenous bolus?
Veniero Gambaro
Il Farmaco (Societa Chimica Italiana : 1989), 58(9) (2003)
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