SML0909
平痛新 盐酸盐
≥98% (HPLC), neurotransmitter reuptake inhibitor, powder
别名:
3,4,5,6-四氢-5-甲基-1-苯基-1H-2,5-氧氮苯并辛因 盐酸盐
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关于此项目
经验公式（希尔记法）:
C17H19NO · HCl
化学文摘社编号:
分子量:
289.80
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
245-585-5
MDL number:
产品名称
平痛新 盐酸盐, ≥98% (HPLC)
InChI key
CNNVSINJDJNHQK-UHFFFAOYSA-N
InChI
1S/C17H19NO.ClH/c1-18-11-12-19-17(14-7-3-2-4-8-14)16-10-6-5-9-15(16)13-18;/h2-10,17H,11-13H2,1H3;1H
SMILES string
Cl.CN1CCOC(c2ccccc2)c3ccccc3C1
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
mp
260 °C (dec.) (lit.)
solubility
H2O: 5 mg/mL, clear
storage temp.
2-8°C
Quality Level
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Application
Nefopam hydrochloride has been used as a standard for the quantitative determination of tramadol by gas chromatography–mass spectrometry (GC/MS).
Biochem/physiol Actions
Nefopam is a centrally-acting analgesic drug of the benzoxazocine chemical class. Nefopam is a non-opioid, but has a potentiating effect on morphine and other opioids. Its mechanism of action is not certain, but may involve its action as a dopamine/serotonin/norepinephrine reuptake inhibitor.
Nefopam is a centrally-acting non-opioid analgesic drug of the benzoxazocine chemical class.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Raymond Poon et al.
PloS one, 7(5), e37940-e37940 (2012-06-06)
Fibroproliferative disorders include neoplastic and reactive processes (e.g. desmoid tumor and hypertrophic scars). They are characterized by activation of β-catenin signaling, and effective pharmacologic approaches are lacking. Here we undertook a high throughput screen using human desmoid tumor cell cultures
Bethan L Richards et al.
The Journal of rheumatology. Supplement, 90, 28-33 (2012-09-04)
To determine the efficacy and safety of neuromodulators for pain management in patients with inflammatory arthritis. A Cochrane systematic review was performed as part of the 3e Initiative on pain management in inflammatory arthritis. We searched Medline, Embase, and Cochrane
F Remérand et al.
Orthopaedics & traumatology, surgery & research : OTSR, 99(2), 169-174 (2012-12-26)
Multimodal analgesia combining several non-opioid analgesics is recommended for pain control after surgery. In one study of total hip arthroplasty (THA), pain relief achieved by adding ketamine to the paracetamol-ketoprofen combination was statistically significant but remained inadequate in most patients.
Yoshie Taniguchi et al.
Anesthesia and analgesia, 111(2), 409-414 (2010-06-10)
Mild hypothermia has been shown to improve neurologic outcome after cardiac arrest. Nefopam, a centrally acting, nonsedative analgesic, decreases the threshold of shivering, but not vasoconstriction, and thus might be a suitable drug for induction of therapeutic hypothermia. However, not
O Mialon et al.
Journal de gynecologie, obstetrique et biologie de la reproduction, 40(2), 137-143 (2010-10-12)
Analgesic protocols administered before a follicular puncture under local anesthesia are well tolerated when using NSAIDs, but we still do not know their possible impacts on in vitro fertilization (IVF) outcomes. A retrospective monocentric study using two consecutive temporal cohorts
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