SML0909
平痛新 盐酸盐
≥98% (HPLC), neurotransmitter reuptake inhibitor, powder
别名:
3,4,5,6-四氢-5-甲基-1-苯基-1H-2,5-氧氮苯并辛因 盐酸盐
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关于此项目
经验公式（希尔记法）:
C17H19NO · HCl
化学文摘社编号:
分子量:
289.80
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
平痛新 盐酸盐, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to beige
mp
260 °C (dec.) (lit.)
溶解性
H2O: 5 mg/mL, clear
储存温度
2-8°C
SMILES字符串
Cl.CN1CCOC(c2ccccc2)c3ccccc3C1
InChI
1S/C17H19NO.ClH/c1-18-11-12-19-17(14-7-3-2-4-8-14)16-10-6-5-9-15(16)13-18;/h2-10,17H,11-13H2,1H3;1H
InChI key
CNNVSINJDJNHQK-UHFFFAOYSA-N
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应用
Nefopam hydrochloride has been used as a standard for the quantitative determination of tramadol by gas chromatography–mass spectrometry (GC/MS).
生化/生理作用
Nefopam is a centrally-acting analgesic drug of the benzoxazocine chemical class. Nefopam is a non-opioid, but has a potentiating effect on morphine and other opioids. Its mechanism of action is not certain, but may involve its action as a dopamine/serotonin/norepinephrine reuptake inhibitor.
Nefopam is a centrally-acting non-opioid analgesic drug of the benzoxazocine chemical class.
特点和优势
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
F Remérand et al.
Orthopaedics & traumatology, surgery & research : OTSR, 99(2), 169-174 (2012-12-26)
Multimodal analgesia combining several non-opioid analgesics is recommended for pain control after surgery. In one study of total hip arthroplasty (THA), pain relief achieved by adding ketamine to the paracetamol-ketoprofen combination was statistically significant but remained inadequate in most patients.
Jean-Francois Payen et al.
Journal of critical care, 28(4), 534-534 (2013-03-26)
We searched for factors independently associated with the prescription of multimodal (balanced) analgesia in mechanically ventilated critically ill patients. In this post hoc analysis of a cohort study, 172 patients who received a combination of 1 opioid with nonopioids, that
A C Van Elstraete et al.
Minerva anestesiologica, 79(3), 232-239 (2012-12-18)
The analgesic efficacy of nefopam and of paracetamol has been shown in the postoperative period after mild- and moderate-pain surgery. The aim of this study was to define the median effective analgesic doses of each drug and of their combination
H Seddik et al.
Annales pharmaceutiques francaises, 71(2), 119-122 (2013-03-30)
Whether intestinal toxicity of preferential or selective COX-2 inhibitors is reduced compared with that of standard NSAIDs is controversial. A 26-year-old woman presented with acute abdominal pain and bloody diarrhoea a few days after beginning meloxicam treatment. Endoscopic examination of
Bethan L Richards et al.
The Journal of rheumatology. Supplement, 90, 28-33 (2012-09-04)
To determine the efficacy and safety of neuromodulators for pain management in patients with inflammatory arthritis. A Cochrane systematic review was performed as part of the 3e Initiative on pain management in inflammatory arthritis. We searched Medline, Embase, and Cochrane
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