SML0952
NSC23766 三盐酸盐
≥97% (HPLC), Rac1 inhibitor, powder
别名:
N6- [2-（4-二乙氨基-1-甲基-丁氨基）-6-甲基-嘧啶-4-基]-2-甲基-喹啉-4,6-二胺 三盐酸盐
产品名称
NSC23766 三盐酸盐, ≥97% (HPLC)
SMILES string
Cl.Cl.Cl.N(CCCC(Nc1nc(cc(n1)C)Nc2cc3c(nc(cc3N)C)cc2)C)(CC)CC
InChI
1S/C24H35N7.3ClH/c1-6-31(7-2)12-8-9-16(3)27-24-28-18(5)14-23(30-24)29-19-10-11-22-20(15-19)21(25)13-17(4)26-22;;;/h10-11,13-16H,6-9,12H2,1-5H3,(H2,25,26)(H2,27,28,29,30);3*1H
InChI key
CPUHORIUXPQCHW-UHFFFAOYSA-N
assay
≥97% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 10 mg/mL, clear
storage temp.
−20°C
Quality Level
Application
NSC23766 三盐酸盐已被用作 ras 相关的 C3 肉毒毒素底物 1 (RAC1) 抑制剂。
Biochem/physiol Actions
NSC23766 是一种 Rac1 抑制剂，一种 Rho 家族 gtp 酶。该化合物通过鸟嘌呤核苷酸交换因子 Trio 和 Tiam1 阻断活化，但不影响与 RhoA 或 Cdc42 的相互作用。NSC23766 阻断 ADP 介导的血小板聚集。NSC23766 对 Rac1 的抑制通过恢复 ErbB2 的下调恢复曲妥珠单抗的敏感性。
NSC23766 是一种 Rac1 抑制剂，一种Rho 家族 gtp 酶。
Features and Benefits
该化合物是环核苷酸研究的特色产品。 点击此处 ，发现更多特色环核苷酸产品。前往 sigma.com/discover-bsm了解更多关于其他研究领域的生物活性小分子。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Takumi Kawaue et al.
Developmental cell, 58(4), 267-277 (2023-02-22)
The number of cells in tissues is controlled by cell division and cell death, and its misregulation could lead to pathological conditions such as cancer. To maintain the cell numbers, a cell-elimination process called apoptosis also stimulates the proliferation of
Ruifeng Lu et al.
Scientific reports, 6, 38249-38249 (2016-12-03)
The generation of cell polarity is essential for the development of multi-cellular organisms as well as for the function of epithelial organs in the mature animal. Small GTPases regulate the establishment and maintenance of polarity through effects on cytoskeleton, membrane
1α, 25 (OH) 2D3 Induces Actin Depolymerization in Endometrial Carcinoma Cells by Targeting RAC1 and PAK1.
Zeng N, et al.
Cellular Physiology and Biochemistry, 40(6), 1455-1464 (2016)
Zhigang Li et al.
Journal of immunology (Baltimore, Md. : 1950), 199(9), 3176-3186 (2017-09-28)
In elderly patients, bacterial infection often causes severe complications and sepsis. Compared to younger patients, older patients are more susceptible to sepsis caused by respiratory infection. Macrophage (Mϕ) phagocytosis of bacteria plays a critical role in the clearance of pathogens
Elaine Vermaak et al.
Virology, 497, 217-232 (2016-08-09)
Cellular pathways involved in cell entry by African horse sickness virus (AHSV), a member of the Orbivirus genus within the Reoviridae family, have not yet been determined. Here, we show that acidic pH is required for productive infection of BSR
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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