SMILES string
N1(CCC(=Cc2cc3c(cc2)OCO3)C1=O)C=O
InChI key
LZGGUFLRKIMBDQ-UHFFFAOYSA-N
InChI
1S/C13H11NO4/c15-7-14-4-3-10(13(14)16)5-9-1-2-11-12(6-9)18-8-17-11/h1-2,5-7H,3-4,8H2
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
room temp
Quality Level
相关类别
Application
KNK437已用于:
- 作为热休克因子1（HSF1）抑制剂用于研究其对耐化学性小鼠细胞活力和凋亡激活的抑制作用
- 作为HSF1抑制剂用于研究其对结肠直肠癌细胞活力和凋亡的影响
- 作为热休克蛋白70（HSP70）抑制剂用于研究其对谷氨酰胺诱导的HSP70和炎症介质释放的影响
Biochem/physiol Actions
KNK437 抑制热激蛋白（包括 hsp -27、-40、-70、-72 和 -105）的积累。 KNK437 比槲皮素更有效地抑制细胞的耐热性。
KNK437 是一种亚苄基内酰胺化合物。
KNK437 是一种热激蛋白抑制剂。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
S Yokota et al.
Cancer research, 60(11), 2942-2948 (2000-06-13)
Cells exposed to heat or other types of stressors transiently synthesize a group of proteins known as heat shock proteins (HSPs). A nonlethal heat treatment can elicit in the cells an ability to resist subsequent lethal heat treatments. We report
An in vitro model to consider the effect of 2 mM glutamine and KNK437 on endotoxin-stimulated release of heat shock protein 70 and inflammatory mediators
Marino L V, et al.
Nutrition, 32(3), 375-383 (2016)
Heat shock factor 1 epigenetically stimulates glutaminase-1-dependent mTOR activation to promote colorectal carcinogenesis
Li J, et al.
Molecular Therapy, 26(7), 1828-1839 (2018)
Metabolic enzyme PDK3 forms a positive feedback loop with transcription factor HSF1 to drive chemoresistance
Xu J, et al.
Theranostics, 9(10), 2999-2999 (2019)
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DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
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