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Merck
CN

SML0999

Sigma-Aldrich

ME0328

≥98% (HPLC)

别名:

(S)-3,4-Dihydro-4-oxo-N-(1-phenylethyl)-2-quinazolinepropanamide

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关于此项目

经验公式（希尔记法）:
C19H19N3O2
化学文摘社编号:
1445251-22-8
分子量:
321.37
UNSPSC代码:
12352200
NACRES:
NA.77

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质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 10 mg/mL, clear

储存温度

room temp

SMILES字符串

[nH]1c2c([c](nc1CCC(=O)N[C@@H](C)c3ccccc3)=O)cccc2

InChI

1S/C19H19N3O2/c1-13(14-7-3-2-4-8-14)20-18(23)12-11-17-21-16-10-6-5-9-15(16)19(24)22-17/h2-10,13H,11-12H2,1H3,(H,20,23)(H,21,22,24)/t13-/m0/s1

InChI key

QIHBWVVVRYYYRO-ZDUSSCGKSA-N

相关类别

生化/生理作用

ME0328 is a selective inhibitor of ADP-ribosyltransferase-3/poly(ADP-ribose) polymerase-3 (ARTD3/PARP3), a PARP family member involved in DNA repair.
ME0328 is a selective inhibitor of ADP-ribosyltransferase-3/poly(ADP-ribose) polymerase-3 (ARTD3/PARP3), a PARP family member involved in DNA repair. ME0328 is the most potent isomer of the four ARTD3 ADP-ribosyltransferase inhibitors. ME0328 selectively inhibits ARTD3 (IC50 of 890 nM) with weaker activity against ARTD1 and ARTD2 (IC50 6.3 and 10.8 μM, respectively), and no significant activity (IC50 >30 μM) against any other ARTD enzyme. ME0328 appears to be the first selective inhibitor of ARTD3/PARP3.

特点和优势

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number
044M4605V

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Bioactive Molecules for Apoptosis

Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.

Discover Bioactive Small Molecules for Cell Cycle

Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.

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