Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
SMILES string
n1ccc(cc1)C(=O)\C=C\c2nc3c(cc2)cccc3
InChI
1S/C17H12N2O/c20-17(14-9-11-18-12-10-14)8-7-15-6-5-13-3-1-2-4-16(13)19-15/h1-12H/b8-7+
InChI key
UJJUKZPBUMCSJZ-BQYQJAHWSA-N
Application
PFK15，一种 PFKFB3 抑制剂，已用于研究其对横纹肌肉瘤（RD）细胞自噬和增殖的调节作用。
Biochem/physiol Actions
PFK15 也称为 1-（4-吡啶基）-3-（2-喹啉基）-2-丙烯-1-酮。它可以防止横纹肌肉瘤的细胞自噬和繁殖。PFK15 通过线粒体途径导致胃癌细胞死亡。它还在体内阻断 MKN45（人胃癌细胞系）肿瘤的生长。PFK15 促进细胞周期停滞，并改变关键细胞周期蛋白的上调。
PFK15 是 PFKB3 的高效和选择性拮抗剂。
PFK15 是 PFKB3（6-磷酸果糖-2-激酶/果糖-2,6-双磷酸酶 3）的高效和选择性拮抗剂，可导致癌细胞和转化的细胞快速凋亡。PFK15 抑制 LLC 异种移植物的生长。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
商品
DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
PFK15, a PFKFB3 antagonist, inhibits autophagy and proliferation in rhabdomyosarcoma cells.
Wang C, et al.
International Journal of Molecular Medicine, 42(1), 359-367 (2018)
PFK15, a small molecule inhibitor of PFKFB3, induces cell cycle arrest, apoptosis and inhibits invasion in gastric cancer.
Zhu W, et al.
PLoS ONE, 11(9), e0163768-e0163768 (2016)
Lingyan Jiang et al.
Nature communications, 12(1), 879-879 (2021-02-11)
Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here we show that macrophages infected with S. Typhimurium exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates. The effects on serine synthesis are mediated by
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML1009-25MG | 04061832724386 |
| SML1009-5MG | 04061832724393 |