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Merck
CN

SML1023

Sigma-Aldrich

Flucloxacillin sodium

≥95% (HPLC), β-lactam antibiotic, powder

别名:

(2S,5R,6R)-6-[[[3-(2-Chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium, BRL 2039 sodium, FK 900 sodium, Floxacillin sodium

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关于此项目

经验公式（希尔记法）:
C19H16ClFN3O5S · Na
CAS Number:
1847-24-1
分子量:
475.85
EC 号:
217-428-0
UNSPSC代码:
12352200
NACRES:
NA.77

主要文件

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Product Name

Flucloxacillin sodium, ≥95% (HPLC)

质量水平

100

方案

≥95% (HPLC)

表单

powder

储存条件

protect from light

颜色

white to beige

储存温度

−20°C

SMILES字符串

[Na+].Fc1c(c(ccc1)Cl)c2n[o]c(c2\C(=N\[C@H]3[C@H]4SC([C@@H](N4C3=O)C(=O)O)(C)C)\[O-])C

InChI

1S/C19H17ClFN3O5S.Na/c1-7-10(12(23-29-7)11-8(20)5-4-6-9(11)21)15(25)22-13-16(26)24-14(18(27)28)19(2,3)30-17(13)24;/h4-6,13-14,17H,1-3H3,(H,22,25)(H,27,28);/q;+1/p-1/t13-,14+,17-;/m1./s1

InChI key

OTEANHMVDHZOPB-SLINCCQESA-M

相关类别

一般描述

Flucloxacillin sodium, a sodium salt of flucloxacillin, is a member of the penicillin class.

应用

Flucloxacillin sodium has been used as a β-lactam antibiotic to study its effects on methicillin-resistant Staphylococcus aureus (MRSA) ΔfloA mutant.

生化/生理作用

Flucloxacillin exhibits antimicrobial property.
Flucloxacillin is a narrow-spectrum β-lactam antibiotic used to treat Gram-positive bacterial infections. Flucloxacillin induces cholestatic liver damage.
Flucloxacillin is a narrow-spectrum β-lactam antibiotic.

其他说明

Light sensitive

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000457080
0000457081
0000457080
0000457081
0000431607

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Handbook of Pharmaceutical Excipients (2014)
Apparent Molar Volume, Adiabatic Compressibility, and Critical Micelle Concentration of Flucloxacillin Sodium in Aqueous NaCl Solutions at Different Temperatures
Khatun MR, et al.
Journal of Chemical and Engineering Data, 61(1), 102-113 (2016)
Membrane microdomain disassembly inhibits MRSA antibiotic resistance
Garcaa-Fernandez E, et al.
Cell, 171(6), 1354-1367 (2017)
Esther García-Fernández et al.
Cell, 171(6), 1354-1367 (2017-11-07)
A number of bacterial cell processes are confined functional membrane microdomains (FMMs), structurally and functionally similar to lipid rafts of eukaryotic cells. How bacteria organize these intricate platforms and what their biological significance is remain important questions. Using the pathogen
Ryan Nattrass et al.
Toxicological sciences : an official journal of the Society of Toxicology, 146(1), 146-156 (2015-04-17)
There are currently no animal models of drug-induced liver injury (DILI) where the adaptive immune system has been shown to damage the liver. Thus, it is difficult to explore the mechanistic basis of the tissue injury. The aim of this

商品

Bioactive Molecules for Immunology Research

Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

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