SML1039
ENMD-1068 盐酸盐
≥97% (HPLC)
别名:
6-Amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone hydrochloride
SMILES string
N1(CCN(CC1)C(=O)CCCCCN)C(=O)CC(C)C
InChI
1S/C15H29N3O2/c1-13(2)12-15(20)18-10-8-17(9-11-18)14(19)6-4-3-5-7-16/h13H,3-12,16H2,1-2H3
InChI key
VRZYMMVEALDDBH-UHFFFAOYSA-N
assay
≥97% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 25 mg/mL, clear
storage temp.
2-8°C
Quality Level
Application
ENMD-1068 hydrochloride has been used as a protease-activated receptor 2 (PAR2) antagonist to determine the pathway responsible for paw edema induced by Crotalus durissus terrificus venom serine protease (Cdtsp 2).
Biochem/physiol Actions
ENMD-1068 hydrochloride exhibits anti-angiogenic and anti-inflammatory activities.
ENMD-1068 is an antagonist of protease-activated receptor 2 (PAR2).
ENMD-1068 is an antagonist of protease-activated receptor 2 (PAR2). The compound blocks TNFα production in synovial explants from patients with arthritis, and inhibits mast cell tryptase-induced recruitment of eosinophils into the pleural cavity of mice.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Caroline R C Costa et al.
International journal of molecular sciences, 19(8) (2018-08-17)
Snake venom serine proteases (SVSPs) represent an essential group of enzymatic toxins involved in several pathophysiological effects on blood homeostasis. Some findings suggest the involvement of this class of enzymatic toxins in inflammation. In this paper, we purified and isolated
Yifeng Wang et al.
American journal of obstetrics and gynecology, 210(6), 531-531 (2014-02-06)
Protease-activated receptor 2 plays an important role in the pathogenesis of endometriosis. We studied the effect of ENMD-1068, a protease-activated receptor 2 antagonist, on the development of endometriosis in a noninvasive fluorescent mouse model. A red fluorescent protein-expressing xenograft model
商品
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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