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SML1039

ENMD-1068 盐酸盐

≥97% (HPLC)

别名:

6-Amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone hydrochloride

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关于此项目

经验公式（希尔记法）:
C15H29N3O2 · HCl
化学文摘社编号:
789488-77-3
分子量:
319.87
UNSPSC Code:
51111800
NACRES:
NA.77
Assay:
≥97% (HPLC)
Form:
powder
Storage condition:
desiccated
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Quality Segment

assay

≥97% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 25 mg/mL, clear

storage temp.

2-8°C

SMILES string

N1(CCN(CC1)C(=O)CCCCCN)C(=O)CC(C)C

InChI

1S/C15H29N3O2/c1-13(2)12-15(20)18-10-8-17(9-11-18)14(19)6-4-3-5-7-16/h13H,3-12,16H2,1-2H3

InChI key

VRZYMMVEALDDBH-UHFFFAOYSA-N

Application

ENMD-1068 hydrochloride has been used as a protease-activated receptor 2 (PAR2) antagonist to determine the pathway responsible for paw edema induced by Crotalus durissus terrificus venom serine protease (Cdtsp 2).

Biochem/physiol Actions

ENMD-1068 hydrochloride exhibits anti-angiogenic and anti-inflammatory activities.
ENMD-1068 is an antagonist of protease-activated receptor 2 (PAR2).
ENMD-1068 is an antagonist of protease-activated receptor 2 (PAR2). The compound blocks TNFα production in synovial explants from patients with arthritis, and inhibits mast cell tryptase-induced recruitment of eosinophils into the pleural cavity of mice.

象形图

Exclamation mark
GHS07

警示词

Warning

危险代码

H302

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

WGK

WGK 3

闪点 (F)

Not applicable

闪点 (°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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